Journal ArticleDOI
Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.
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TLDR
The study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice, and substitution of the Rome pain criterion for the New York pain criterion is proposed.Abstract:
The New York and the Rome diagnostic criteria for ankylosing spondylitis (AS) and the clinical history screening test for AS were evaluated in relatives of AS patients and in population control subjects. The New York criterion of pain in the (dorso) lumbar spine lacks specificity, and the chest expansion criterion is too insensitive. The Rome criterion of low back pain for more than 3 months is very useful. Our study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice. As a modification of the New York criteria, substitution of the Rome pain criterion for the New York pain criterion is proposed.read more
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Journal ArticleDOI
Association of interleukin-23 receptor variants with ankylosing spondylitis.
Proton Rahman,Robert D. Inman,Dafna D. Gladman,Jeff Reeve,Lynette Peddle,Walter P. Maksymowych +5 more
TL;DR: This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis.
Journal ArticleDOI
The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis
Blanca Rueda,Gisela Orozco,Enrique Raya,José Luis Fernández-Sueiro,Juan Mulero,Francisco J. Blanco,Carlos Vilches,Miguel A. González-Gay,Javier Martin +8 more
TL;DR: Investigation of the possible involvement of the IL23R gene in genetic susceptibility to ankylosing spondylitis suggests that it seems to be involved in AS genetic predisposition.
Journal ArticleDOI
The Natural Course of Radiographic Progression in Ankylosing Spondylitis — Evidence for Major Individual Variations in a Large Proportion of Patients
TL;DR: Patients with ankylosing spondylitis who had never received anti-tumor necrosis factor therapy are analyzed to differentiate patients on an individual level according to their progression rates, assessed by counting new syndesmophytes.
Journal ArticleDOI
Symptomatic efficacy of etanercept and its effects on objective signs of inflammation in early nonradiographic axial spondyloarthritis: a multicenter, randomized, double-blind, placebo-controlled trial.
Maxime Dougados,Désirée van der Heijde,Joachim Sieper,Jürgen Braun,Walter P. Maksymowych,Gustavo Citera,Corinne Miceli-Richard,James Cheng-Chung Wei,Ron Pedersen,R. Bonin,Mahboob Rahman,Isabelle Logeart,Joseph Wajdula,Andrew S Koenig,Bonnie Vlahos,Daniel F. Alvarez,Jack F. Bukowski +16 more
TL;DR: To assess the efficacy of etanercept in the treatment of early active nonsteroidal antiinflammatory drug (NSAID)–refractory nonradiographic axial spondyloarthritis (SpA).
Journal ArticleDOI
Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis.
Walter P. Maksymowych,Robert Landewé,Barbara Conner-Spady,Maxime Dougados,Herman Mielants,Hille van der Tempel,A. Robin Poole,Nandi Wang,Désirée van der Heijde +8 more
TL;DR: Results indicate that MMP-3 is a significant independent predictor of radiographic progression in patients with AS, particularly in those with preexisting radiographic damage.
References
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Journal ArticleDOI
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Journal ArticleDOI
Clinical history as a screening test for ankylosing spondylitis.
TL;DR: A controlled study demonstrated that the clinical history may be sensitive and specific in the differential diagnosis of ankylosing spondylitis when reliance of five specific historic features is made.
Journal ArticleDOI
The Epidemiology of Chronic Rheumatism
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Journal ArticleDOI
The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population.
TL;DR: The discriminatory value of the New York criterion of history of pain or the presence of pain at the dorsolumbar junction or in the lumbar spine was analyzed in the population and family studies and was found to be too nonspecific.
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