Journal ArticleDOI
Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.
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TLDR
The study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice, and substitution of the Rome pain criterion for the New York pain criterion is proposed.Abstract:
The New York and the Rome diagnostic criteria for ankylosing spondylitis (AS) and the clinical history screening test for AS were evaluated in relatives of AS patients and in population control subjects. The New York criterion of pain in the (dorso) lumbar spine lacks specificity, and the chest expansion criterion is too insensitive. The Rome criterion of low back pain for more than 3 months is very useful. Our study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice. As a modification of the New York criteria, substitution of the Rome pain criterion for the New York pain criterion is proposed.read more
Citations
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Journal ArticleDOI
Circulating microRNAs as potential biomarkers of disease activity and structural damage in ankylosing spondylitis patients.
Carlos Perez-Sanchez,Pilar Font-Ugalde,Patricia Ruiz-Limon,Chary López-Pedrera,M.C. Castro-Villegas,Maria del Carmen Abalos-Aguilera,Nuria Barbarroja,Iván Arias de la Rosa,María Dolores López-Montilla,Alejandro Escudero-Contreras,Clementina López-Medina,Eduardo Collantes-Estevez,Yolanda Jimenez-Gomez +12 more
TL;DR: A six-plasma microRNA signature that could be attractive candidates as non-invasive biomarkers for the AS diagnosis, and may help to elucidate the disease pathogenesis is identified.
Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects
Fernando Pimentel-Santos,Fernando Pimentel-Santos,Dário Ligeiro,Margarida Gaspar de Matos,Ana Filipa Mourão,José Costa,Helena Santos,Anabela Barcelos,Fátima Godinho,Patrícia Rosado Pinto,Margarida Cruz,João Eurico Fonseca,Henrique Guedes-Pinto,Jaime Branco,Matthew A. Brown,Gethin P. Thomas +15 more
TL;DR: A whole-genome microarray approach was undertook to identify candidate genes associated with AS and validated these gene-expression changes in a larger sample cohort and identified strong candidate genes that may play roles in both the inflammatory and joint destruction aspects of the disease.
Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS
TL;DR: Differences in global gene expression patterns between patients with AS and controls are shown, suggesting an immunosuppressive phenotype in the patients, and downregulated expression of three immune-related genes was confirmed.
Journal ArticleDOI
Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis
Gia Deyab,Ingrid Hokstad,Jon Elling Whist,Milada Cvancarova Småstuen,Stefan Agewall,Stefan Agewall,Torstein Lyberg,Nicoletta Ronda,Knut Mikkelsen,Gunnbjørg Hjeltnes,Ivana Hollan +10 more
TL;DR: Treatment with MTX and anti-TNF ± MTX was associated with a relatively fast improvement of EF in IA patients with ED, independent of change in disease activity, and modes of action other than the anti-inflammatory effect may contribute to the EF improvement.
Journal ArticleDOI
MICA allele typing of HLA-B27 positive japanese patients with seronegative spondylarthropathies and healthy individuals: Differential linkage disequilibrium with HLA-B27 subtypes
Naoyuki Tsuchiya,Michiko Shiota,Satoshi Moriyama,Atsuko Ogawa,Miki Komatsu-Wakui,Hiroshi Mitsui,Daniel E. Geraghty,Katsushi Tokunaga +7 more
TL;DR: Direct involvement of MICA polymorphism in the pathogenesis seems to be unlikely, however, such information will provide a useful tool for elucidating the evolutional pathway of HLA-B27 subtypes as well as the contribution of other genes within the MHC region in the Pathogenesis of these diseases.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
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Preliminary criteria for the classification of systemic sclerosis (scleroderma)
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Journal ArticleDOI
Clinical history as a screening test for ankylosing spondylitis.
TL;DR: A controlled study demonstrated that the clinical history may be sensitive and specific in the differential diagnosis of ankylosing spondylitis when reliance of five specific historic features is made.
Journal ArticleDOI
The Epidemiology of Chronic Rheumatism
TL;DR: The human hand is a fascinating subject, an actor of many roles and disguises: the man in miniature, revealing its owner's story, here is a book which sets out to teach us how best to examine it and is disappointing because it is only 50 per cent of the classic it might have been
Journal ArticleDOI
The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population.
TL;DR: The discriminatory value of the New York criterion of history of pain or the presence of pain at the dorsolumbar junction or in the lumbar spine was analyzed in the population and family studies and was found to be too nonspecific.
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