Journal ArticleDOI
Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro.
Mehmet Sarimahmut,Necmiye Balikci,Serap Celikler,Ferda Ari,Engin Ulukaya,Gürcan Güleryüz,Mustafa Z. Ozel +6 more
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TLDR
The results suggest that H. adenotrichum might show both cytotoxic and genotoxic effects depending on the cell type, which should be taken into account in its use for therapeutic purposes.About:
This article is published in Regulatory Toxicology and Pharmacology.The article was published on 2016-02-01. It has received 16 citations till now. The article focuses on the topics: Genotoxicity & Sister chromatid exchange.read more
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Regulatory landscape of nanotechnology and nanoplastics from a global perspective.
Jacqueline Allan,Susanne Belz,Arnd Hoeveler,Marta Hugas,Haruhiro Okuda,Anil K. Patri,Hubert Rauscher,Primal Silva,William Slikker,Birgit Sokull-Kluettgen,Weida Tong,Elke Anklam +11 more
TL;DR: It has been revealed that there are still some uncertainties and knowledge gaps with regard to physicochemical properties, environmental behaviour and toxicological effects, especially as testing described in the dossiers is often done early in the product development process, and the material in the final product may behave differently.
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Hypericum spp.: An Update on the Biological Activities and Metabolic Profiles.
TL;DR: The aim of this review is to provide an update of most recent studies about biological investigations of plants belonging to Hypericum genus, and to present a spectrum of secondary metabolites not previously identified in this genus.
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Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations.
Onur Bender,Eulogio J. Llorent-Martínez,Gokhan Zengin,Adriano Mollica,Ramazan Ceylan,L. Molina-García,Maria Luisa Fernández-de Córdova,Arzu Atalay +7 more
TL;DR: The findings suggest that Hypericum salsugineum could be valued as a potential source of biologically-active compounds for designing novel products.
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Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method
TL;DR: It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatibility and biocompatible, none of the nanocomPOSites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity.
References
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
Flora of Turkey and the East Aegean Islands
Abstract: Flora of Turkey and the East Aegean Islands , Flora of Turkey and the East Aegean Islands , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
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Flora of Turkey and the East Aegean Islands.
TL;DR: Flora of Turkey and the East Aegean Islands as discussed by the authors, Flora of Turkish and the east coast of Turkey, and the south-east islands of Turkey are mentioned in this paper.
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New Giemsa method for the differential staining of sister chromatids
Paul Perry,Sheldon Wolff +1 more
TL;DR: If human lymphocytes1 or Chinese hamster2 cells are treated with the base analogue 5-bromodeoxyuridine in the latter part of the S period, Giemsa stained chromosomes exhibit a pattern of condensed and extended segments along their length, allowing the identification of the two chromatids, and the observation of sister chromatid exchanges (SCEs) without recourse to autoradiography.
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Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.