Journal ArticleDOI
Evaluation of penicillin hypersensitivity: Value of clinical history and skin testing with penicilloyl-polylysine and penicillin G: A cooperative prospective study of the penicillin study group of the American Academy of Allergy
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Abstract:
A multicenter cooperative study of almost 3,000 patients by members of the Penicillin Study Group of the American Academy of Allergy has confirmed the usefulness of skin tests to penicillin G (Pen G) and penicilloyl-polylysine (PPL) in the evaluation of penicillin hypersensitivity. Nineteen percent of 1,718 patients with a history of penicillin allergy had positive skin tests to either or both agents, vs 7% of 1,229 patients with no such history. Among patients with a history of penicillin allergy where a detailed history was available, positive skin tests were noted in 46% with a history of anaphylaxis, 17% with a history of urticaria or angioneurotic edema, and 7% with a history of a maculopapular reaction. PPL Generally gave somewhat higher reaction rates than Pen G, but both skin tests were needed to elicit the maximum number of reactors. After skin tests were completed, 379 patients were challenged with penicillin. Six percent of patients with a positive history had an allergic reaction vs 2% of patients with a negative history. However, 67% of the 9 challenged patients with a positive skin test had an allergic reaction, and half of these were immediate or early systemic reactions. Only 3% of the 346 challenged patients with a negative skin test had a reaction to challenge and only one fourth of these had early reactions thought to be possibly mediated by IgE.read more
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Drug allergy: an updated practice parameter.
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The diagnosis and management of anaphylaxis practice parameter: 2010 update.
Phillip Lieberman,Richard A. Nicklas,John Oppenheimer,Stephen F. Kemp,David M. Lang,David I. Bernstein,Jonathan A. Bernstein,A. Wesley Burks,Anna M. Feldweg,Jordan N. Fink,Paul A. Greenberger,David B.K. Golden,John M. James,Dennis K. Ledford,Albert L. Sheffer,Joann Blessing-Moore,Linda Cox,David A. Khan,Jay M. Portnoy,Christopher Randolph,Diane E. Schuller,Sheldon L. Spector,Stephen A. Tilles,Dana Wallace +23 more
TL;DR: These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology, the ACAAI, and the Joint Council of All allergy, asthma and Immunology and are not designed for use by pharmaceutical companies in drug promotion.
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Allergy diagnostic testing: An updated practice parameter
I. Leonard Bernstein,James T. Li,David I. Bernstein,Robert G. Hamilton,Sheldon L. Spector,Ricardo A. Tan,Scott H. Sicherer,David B.K. Golden,David A. Khan,Richard A. Nicklas,Jay M. Portnoy,Joann Blessing-Moore,Linda Cox,David M. Lang,John Oppenheimer,Christopher Randolph,Diane E. Schuller,Stephen A. Tilles,Dana Wallace,Estelle Levetin,Richard W. Weber +20 more
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The diagnosis and management of anaphylaxis: an updated practice parameter.
Phillip Lieberman,Stephen F. Kemp,John Oppenheimer,David M. Lang,I. Leonard Bernstein,Richard A. Nicklas,John A. Anderson,David I. Bernstein,Jonathan A. Bernstein,Jordan N. Fink,Paul A. Greenberger,Dennis K. Ledford,James T. Li,Albert L. Sheffer,Roland Solensky,Bruce L. Wolf,Joann Blessing-Moore,David A. Khan,Rufus E. Lee,Jay M. Portnoy,Diane E. Schuller,Sheldon L. Spector,Stephen A. Tilles +22 more
TL;DR: These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma and Immunology, the American College of Allergies, ASTI, and ACAAI as mentioned in this paper.
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Diagnosis of immediate allergic reactions to beta‐lactam antibiotics
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References
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Journal ArticleDOI
Studies on the epidemiology of adverse drug reactions. II. An evaluation of penicillin allergy.
TL;DR: Adverse reactions to penicillin occur in 1 to 8 per cent of patients treated, and the different reaction rates are probably related to numerous factors, including the difficulty in attributing reactions specifically to Penicillin, particularly when several drugs are being administered.
Journal ArticleDOI
Studies on the mechanism of the formation of the penicillin antigen. I. Delayed allergic cross-reactions among penicillin G and its degradation products.
TL;DR: The results demonstrate that the diastereomeric BPO groups (predominantly Di-BPO-Lys groups) are major antigenic determinant groups responsible for PG hypersensitivity in rabbits and human beings.
Journal ArticleDOI
Prediction of penicillin allergy by immunological tests
Bernard B. Levine,David M. Zolov +1 more
TL;DR: Skin tests were found to be valuable predictive tests for immediate (including anaphylactic) and accelerated urticarial allergic reactions to penicillin.
Journal ArticleDOI
Penicilloyl-Polylysine as an Intradermal Test of Penicillin Sensitivity
TL;DR: No anaphylaxis or life-threatening reactions occurred in patients with negative skin tests, although on the basis of previous experience this number of cases should have produced four reactions severe enough to require hospitalization.
Journal ArticleDOI
Studies on the epidemiology of adverse drug reactions. IV. The relationship of cephalothin and penicillin allergy.
TL;DR: Cephalothin must be used with caution in the treatment of patients with a history of allergic reactions to penicillin or with positive skin tests with penicilloyl-polylysine, and cannot be considered as a uniformly safe substitute forPenicillin in such patients.