Journal ArticleDOI
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Andréa D.E. Zomkowski,Angelo O. Rosa,Jaime Lin,Adair R.S. Santos,João B. Calixto,Ana Lúcia S. Rodrigues +5 more
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TLDR
It is demonstrated that agmatine antidepressant-like effects in the FST seem to be mediated, at least in part, by an interaction with 5- HT(1A/1B) and 5-HT(2) receptors.About:
This article is published in Brain Research.The article was published on 2004-10-15. It has received 137 citations till now. The article focuses on the topics: Isamoltane & Ritanserin.read more
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Agmatine : metabolic pathway and spectrum of activity in brain.
Angelos Halaris,John Plietz +1 more
TL;DR: In an animal model of acute stress disorder, intraperitoneal agmatine injections diminish contextual fear learning and reduce alcohol and opioid dependence by diminishing behaviour in a rat conditioned place preference paradigm, andAgmatine appears to be an endogenous neuromodulator of mental stress.
Journal ArticleDOI
Agmatine: clinical applications after 100 years in translation
John E. Piletz,John E. Piletz,Feyza Aricioglu,Juei-Tang Cheng,Carolyn A. Fairbanks,Varda H. Gilad,Britta Haenisch,Britta Haenisch,Britta Haenisch,Angelos Halaris,Samin Hong,Jong Eun Lee,Jin Li,Ping Liu,Gerhard J. Molderings,Ana Lúcia S. Rodrigues,Joseph Satriano,Joseph Satriano,Gong Je Seong,George L. Wilcox,Ning Wu,Gad M. Gilad +21 more
TL;DR: This timely review, a concerted effort by 16 independent research groups, draws attention to the substantial preclinical and initial clinical evidence, and highlights challenges and opportunities, for the use of agmatine in treating a spectrum of complex diseases with unmet therapeutic needs.
Journal ArticleDOI
The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors
TL;DR: Results indicate that the antidepressant-like effect of curcumin in the forced swimming test is related to serotonergic system and may be mediated by, at least in part, an interaction with 5- HT(1A/1B) and 5-HT(2C) receptors.
Journal ArticleDOI
Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: Involvement of the monoaminergic system
Daniele G. Machado,Luis E.B. Bettio,Mauricio P. Cunha,Juliano C. Capra,Juliana Bastos Dalmarco,Moacir Geraldo Pizzolatti,Ana Lúcia S. Rodrigues +6 more
TL;DR: The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.
Journal ArticleDOI
Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test.
Olivia F. O’Leary,Olivia F. O’Leary,Anita J. Bechtholt,James J. Crowley,Tiffany E. Hill,Michelle E. Page,Irwin Lucki +6 more
TL;DR: It is demonstrated that endogenous 5-HT synthesis mediates the behavioral effects of SSRIs, but not NRIs, in the TST, whereas disruption of the behavioraleffects of NRI and SSRI antidepressants required disruption of both catecholamine synthesis and vesicular storage and release mechanisms.
References
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Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
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A molecular and cellular theory of depression
TL;DR: These findings constitute the framework for an updated molecular and cellular hypothesis of depression, which posits that stress-induced vulnerability and the therapeutic action of antidepressant treatments occur via intracellular mechanisms that decrease or increase, respectively, neurotrophic factors necessary for the survival and function of particular neurons.
Journal ArticleDOI
The validity of animal models of depression.
TL;DR: The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model.
Journal ArticleDOI
Research and treatment approaches to depression
Ma-Li Wong,Julio Licinio +1 more
TL;DR: The complexity of this field is best approached by rigorous explorations of known candidate systems in conjunction with the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.
Journal ArticleDOI
Is there a role for 5-HT1A agonists in the treatment of depression?
TL;DR: 5-HT1A receptor agonism represents a valuable and efficacious therapeutic approach to major depression and extended-release formulations allow once-daily dosing regimens, thus avoiding sharp peak plasma concentrations and permits the use of higher dosages.
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The tail suspension test: A new method for screening antidepressants in mice
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Porsolt Rd,Bertin A,Jalfre M +2 more