Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users.
Séverine Duvaud,Chiara Gabella,Frédérique Lisacek,Frédérique Lisacek,Heinz Stockinger,Vassilios Ioannidis,Christine Durinx +6 more
TLDR
The Swiss Bioinformatics Resource Portal (expasy) as mentioned in this paper provides a portfolio of reliable and state-of-the-art resources for the storage, analysis and interpretation of biological data.Abstract:
The SIB Swiss Institute of Bioinformatics (https://www.sib.swiss) creates, maintains and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and resources for the storage, analysis and interpretation of biological data. Through Expasy (https://www.expasy.org), the Swiss Bioinformatics Resource Portal, the scientific community worldwide, freely accesses more than 160 SIB resources supporting a wide range of life science and biomedical research areas. In 2020, Expasy was redesigned through a user-centric approach, known as User-Centred Design (UCD), whose aim is to create user interfaces that are easy-to-use, efficient and targeting the intended community. This approach, widely used in other fields such as marketing, e-commerce, and design of mobile applications, is still scarcely explored in bioinformatics. In total, around 50 people were actively involved, including internal stakeholders and end-users. In addition to an optimised interface that meets users' needs and expectations, the new version of Expasy provides an up-to-date and accurate description of high-quality resources based on a standardised ontology, allowing to connect functionally-related resources.read more
Citations
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Applications of Ionic Liquids in Whole-Cell and Isolated Enzyme Biocatalysis.
TL;DR: Ionic liquids have unique chemical properties that have fascinated scientists in many fields as discussed by the authors and the effects of adding ionic liquids to biocatalysts are many and varied, including improved separations and phase behaviour, reduction in toxicity, and stabilization of protein structures.
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The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report.
TL;DR: How these new models helped to solve the crystal structure of a protein involved in the nonsense-mediated mRNA decay pathway, an mRNA quality-control pathway dedicated to the elimination of eukaryotic mRNAs harboring premature stop codons are described and the AlphaFold model largely outcompetes the other models are described.
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Mitochondrial Contact Site and Cristae Organization System and F 1 F O -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae.
Lawrence Rudy Cadena,Lawrence Rudy Cadena,Ondřej Gahura,Brian Panicucci,Alena Zíková,Alena Zíková,Hassan Hashimi,Hassan Hashimi +7 more
TL;DR: In this article, the authors show that MICOS-F1FO-ATP synthase crosstalk is conserved in Trypanosoma brucei, a member of the Discoba clade that separated from the Opisthokonta ∼2 billion years ago.
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Genome-Wide Analysis of the Protein Phosphatase 2C Genes in Tomato
Jian-Hua Qiu,Lei Ni,Xue Xia,Shihao Chen,Yan Zhang,Min Lang,Mengyu Li,Bin Liu,Yunrong Pan,Jinhua Li,Xingguo Zhang +10 more
TL;DR: Evidence is hinted that SlPP2C genes play multiple roles in tomato and may contribute to tomato resistance to bacterial wilt and lay a solid foundation for tomato breeding and transgenic resistance to plant pathogens.
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Drug Design—Past, Present, Future
TL;DR: The present review aims to capture some of the most important milestones in the development of drug design, to outline some ofThe most used current methods and to sketch the future perspective according to the author’s point of view.
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