Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation
Kenneth C. Anderson,Michael P. Bates,B Slaughenhoupt,Geraldine S. Pinkus,Stuart F. Schlossman,Lee M. Nadler +5 more
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TLDR
A hypothetical model is derived that relates the malignant B cell to its normal cellular counterpart on the basis of cell surface expression of this panel of B cell-restricted and B cell -associated antigens.About:
This article is published in Blood.The article was published on 1984-06-01 and is currently open access. It has received 718 citations till now. The article focuses on the topics: B-1 cell & B cell.read more
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Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.
Peter McLaughlin,Antonio J. Grillo-Lopez,Brian K. Link,Ronald Levy,Myron S. Czuczman,Michael E. Williams,M R Heyman,I. Bence-Bruckler,Christine A. White,Fernando Cabanillas,Vinay K. Jain,A D Ho,John Lister,K Wey,D. Shen,Brian Dallaire +15 more
TL;DR: The response rate of 48% with IDEC-C2B8 is comparable to results with single-agent cytotoxic chemotherapy, and further investigation of this agent is warranted, including its use in conjunction with standard chemotherapy.
Journal ArticleDOI
IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma
David G. Maloney,Antonio J. Grillo-Lopez,Christine A. White,David Bodkin,Russell J. Schilder,James A. Neidhart,Nalini Janakiraman,Kenneth A. Foon,Tina Marie Liles,Brian Dallaire,Ken Wey,Ivor Royston,Thomas A. Davis,Ronald Levy +13 more
TL;DR: Likelihood of tumor response was associated with a follicular histology, with the ability to sustain a high serum level of antibody after the first infusion, and with a longer duration of remission to prior chemotherapy, and IDEC-C2B8 has a better safety profile.
Journal ArticleDOI
Efficacy and Safety of Rituximab in Moderately-to-Severely Active Systemic Lupus Erythematosus: The Randomized, Double-Blind, Phase II/III Systemic Lupus Erythematosus Evaluation of Rituximab Trial
Joan T. Merrill,C. Michael Neuwelt,Daniel J. Wallace,Joseph C. Shanahan,Kevin Latinis,Jim C. Oates,Tammy O. Utset,Caroline Gordon,David A. Isenberg,Hsin Ju Hsieh,David Zhang,Paul Brunetta +11 more
TL;DR: The EXPLORER trial enrolled patients with moderately-to-severely active SLE and used aggressive background treatment and sensitive cutoffs for nonresponse, and no differences were noted between placebo and rituximab in the primary and secondary end points.
Journal ArticleDOI
Treatment of Patients With Low-Grade B-Cell Lymphoma With the Combination of Chimeric Anti-CD20 Monoclonal Antibody and CHOP Chemotherapy
Myron S. Czuczman,Antonio J. Grillo-Lopez,Christine A. White,Mansoor N. Saleh,Leo I. Gordon,A. F. LoBuglio,C. Jonas,D. Klippenstein,B. Dallaire,C. Varns +9 more
TL;DR: This is the first report demonstrating the safety and efficacy of Rituxan anti-CD20 chimeric antibody in combination with standard-dose systemic chemotherapy in the treatment of indolent B-cell lymphoma.
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Cellular function and molecular structure of ecto-nucleotidases
TL;DR: The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribution, and physiological and pathophysiological functions.
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Continuous cultures of fused cells secreting antibody of predefined specificity
G Köhler,C. Milstein +1 more
TL;DR: The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor.
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John M. Bennett,Daniel Catovsky,Marie-Theregse Daniel,G. Flandrin,David A. G. Galton,Harvey R. Gralnick,C. Sultan +6 more
TL;DR: A uniform system of classification and nomenclature of the acute leukaemias should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell‐surface markers believed to characterize specific cell types are applied to cases of acuteLeukaemia.
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Kanti R. Rai,Arthur Sawitsky,Eugene P. Cronkite,Arjun D. Chanana,Robert N. Levy,Bernard S. Pasternack +5 more
TL;DR: The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients and sex and age were shown to be poor predictors of survival after adjustment for stage.