Journal ArticleDOI
Facile way to synthesise hydrogel contact lenses with good performance for ophthalmic drug delivery
TLDR
In this article, water and hydrophilic monomer N-vinyl-2-pyrrolidone are introduced in polymerisation to enhance the properties of hydrogel such as gelation time, transparency, structure, swelling and water retention properties.Abstract:
Hydrogel contact lenses are ideal carriers for ophthalmic drug delivery. Conventional poly(hydroxyethyl methacrylate) hydrogel contact lenses have restricted applications in ophthalmic drug delivery due to low oxygen transmissibility. Water and hydrophilic monomer N-vinyl-2-pyrrolidone are introduced in polymerisation to enhance the properties of hydrogel such as gelation time, transparency, structure, swelling and water retention properties in this work. Norfloxacin as a drug model could be loaded into hydrogels by soaking repeatedly. The sustained drug release in a given period is dependent on the characteristics of solution and loading time.read more
Citations
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Journal ArticleDOI
A new route to fabricate biocompatible hydrogels with controlled drug delivery behavior.
Xiaohong Hu,Xiao Gong +1 more
TL;DR: In vitro drug release results showed that copolymer hydrogel with higher MA- β-CD content exhibited a better drug loading capacity and drug release behaviors could be tuned by MA-β-CD/monomer ratio.
Journal ArticleDOI
Functional hydrogel contact lens for drug delivery in the application of oculopathy therapy.
TL;DR: Preliminary in vivo evaluation revealed that functional hydrogel contact lens had better effect and efficacy on lowering intraocular tension than commercial eye drop and it is inferred from all results that functional contact lens has a bright prospect in the application of oculopathy therapy.
Journal ArticleDOI
Surface functionalization of hydrogel by thiol-yne click chemistry for drug delivery
TL;DR: The thiol-yne photopolymerization was utilized to realize β-cyclodextrin (β-CD) functionalized hydrogel in order to improve its performance for drug delivery and hydrophilicity and protein resistant property of hydrogels.
Journal ArticleDOI
Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices
Prina Mehta,Rita Haj-Ahmad,Ali A. Al-Kinani,Muhammad Arshad,Muhammad Arshad,Ming Wei Chang,Raid G. Alany,Zeeshan Ahmad +7 more
TL;DR: This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery, and elucidates current theranostic and diagnostic approaches based on ocular lenses.
Journal ArticleDOI
Ocular Permeation and Sustained Anti-inflammatory Activity of Dexamethasone from Kaolin Nanodispersion Hydrogel System.
Arunima Pramanik,Rudra Narayan Sahoo,Ashirbad Nanda,Rajaram Mohapatra,Ranveer Singh,Subrata Mallick +5 more
TL;DR: Local controlled delivery sustained anti-inflammatory activity of dexamethasone has been achieved using kaolin incorporated HPMC film.
References
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Journal ArticleDOI
Soft contact lens polymers: an evolution
TL;DR: A review of patents and literature reveals an evolution in materials technologies driven by an increased understanding of the physiological needs of the cornea, beginning with the first hydrogel lenses developed by Wichterle, followed by a variety of high water hydrogels.
Journal ArticleDOI
Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review
Li Xinming,Cui Yingde,Andrew W. Lloyd,Sergey V. Mikhalovsky,Susan Sandeman,Carol A. Howel,Liao Liewen +6 more
TL;DR: Polymeric hydrogels for contact lens-based ophthalmic drug delivery systems, their advantages and drawbacks are critically analyzed in this review.
Journal ArticleDOI
Imprinted soft contact lenses as norfloxacin delivery systems.
TL;DR: Results prove that ITC is a useful tool for the optimization of the structure of the imprinted cavities in order to obtain efficient therapeutic soft contact lenses.
Journal ArticleDOI
Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release.
Jinku Xu,Xinsong Li,Fuqian Sun +2 more
TL;DR: The data demonstrate that pHEMA/beta-CD hydrogel contact lenses can effectively deliver puerarin through the cornea and increase the ESR and tensile strength of the hydrogels.
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Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release.
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