Factors promoting acute and chronic diseases caused by yersiniae.
TLDR
The experimental system constructed with the medically significant yersiniae provides a powerful basic model for comparative study of factors required for expression of acute versus chronic disease.Abstract:
The experimental system constructed with the medically significant yersiniae provides a powerful basic model for comparative study of factors required for expression of acute versus chronic disease. The system exploits the close genetic similarity between Yersinia pestis, the etiological agent of bubonic plague, and enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica. Y. pestis possesses three plasmids, of which one, shared by the enteropathogenic species, mediates a number of virulence factors that directly or indirectly promote survival within macrophages and immunosuppression. The two remaining plasmids are unique and encode functions that promote acute disease by enhancing bacterial dissemination in tissues and resistance to phagocytosis by neutrophils and monocytes. These properties are replaced in the enteropathogenic yersiniae by host cell invasins and an adhesin which promote chronic disease; the latter are cryptic in Y. pestis. Additional distinctions include specific mutational losses in Y. pestis which result in loss of fitness in natural environments plus gain of properties that facilitate transmission and infection via fleabite.read more
Citations
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Journal ArticleDOI
Yersinia pestis--etiologic agent of plague.
R D Perry,J D Fetherston +1 more
TL;DR: The present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague is updated.
Journal ArticleDOI
Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
TL;DR: Analysis of the population genetic structure of Y. pestis and the two other pathogenic Yersinia species shows consistent with previous inferences that Antiqua caused a plague pandemic in the sixth century, Medievalis caused the Black Death and subsequent epidemics during the second pandemic wave, and Orientalis cause the current Plague pandemic.
Journal ArticleDOI
The Virulence Plasmid of Yersinia, an Antihost Genome
Guy R. Cornelis,Anne Boland,Aoife Boyd,Cecile C.A.W. Geuijen,Maite Iriarte,Cécile Neyt,Marie-Paule Sory,Isabelle Stainier +7 more
TL;DR: The 70-kb virulence plasmid enables Yersinia spp.
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NATURAL HISTORY OF PLAGUE: Perspectives from More than a Century of Research ∗
Kenneth L. Gage,Michael Kosoy +1 more
TL;DR: The zoonotic nature of the disease and that plague exists in natural cycles involving transmission between rodent hosts and flea vectors are among the most important discoveries.
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Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells
Marie-Paule Sory,Guy R. Cornelis +1 more
TL;DR: The results demonstrate that Y. enterocolitica is able to transfer hybrid proteins into eukaryotic cells and can be used not only to study the mechanism of YopE translocation but also the fate of the other Yops or even of proteins secreted by other bacterial pathogens.
References
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TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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Common themes in microbial pathogenicity.
B. Brett Finlay,Stanley Falkow +1 more
TL;DR: The degree of success of a pathogen is dependent upon the status of the host, and biochemical sensors exquisitely designed to measure and respond to such environmental stimuli and accordingly to regulate a cascade of virulence determinants essential for life within the host.
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Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis.
TL;DR: Yersinia enterocolitica isolates harboring a particular species of plasmid deoxyribonucleic acid showed a high degree of lethality for gerbils and caused the detachment of HEp-2 tissue cell monolayers, but invasiveness of HEP-2 cells was shown not to be a plasmids-mediated property.
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Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia
Kun-Liang Guan,Jack E. Dixon +1 more
TL;DR: Amino acids surrounding an essential Cys residue are highly conserved, as are other amino acids in the Yersinia and mammalian protein tyrosine phosphatases, suggesting that they use a common catalytic mechanism.
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