Journal ArticleDOI
Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function
Hua Hu,Jian Gan,Peter Jonas +2 more
TLDR
Not only are PV+ interneurons involved in basic microcircuit functions, but they also play a role in complex network operations, including expansion of dynamic activity range, pattern separation, modulation of place and grid field shapes, phase precession, and gain modulation of sensory responses.Abstract:
The success story of fast-spiking, parvalbumin-positive (PV(+)) GABAergic interneurons (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy. In 1995, the properties of these interneurons were completely unknown. Twenty years later, thanks to the massive use of subcellular patch-clamp techniques, simultaneous multiple-cell recording, optogenetics, in vivo measurements, and computational approaches, our knowledge about PV(+) interneurons became more extensive than for several types of pyramidal neurons. These findings have implications beyond the "small world" of basic research on GABAergic cells. For example, the results provide a first proof of principle that neuroscientists might be able to close the gaps between the molecular, cellular, network, and behavioral levels, representing one of the main challenges at the present time. Furthermore, the results may form the basis for PV(+) interneurons as therapeutic targets for brain disease in the future. However, much needs to be learned about the basic function of these interneurons before clinical neuroscientists will be able to use PV(+) interneurons for therapeutic purposes.read more
Citations
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Journal ArticleDOI
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
TL;DR: Current understanding of neocortical interneuron diversity and the properties that distinguish cell types are reviewed and it is illustrated how recent advances in the field have shed light onto the mechanisms by which GABAergic inhibition contributes to network operations.
Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons
Naomi Habib,Naomi Habib,Yinqing Li,Matthias Heidenreich,Matthias Heidenreich,Lukasz Swiech,Lukasz Swiech,Inbal Avraham-Davidi,John J. Trombetta,Cynthia C. Hession,Feng Zhang,Aviv Regev,Aviv Regev +12 more
TL;DR: Div-Sequ is developed, which combines scalable single-nucleus RNA-Seq (sNuc-Sepp) with pulse labeling of proliferating cells by 5-ethynyl-2′-deoxyuridine (EdU) to profile individual dividing cells and open the way for unbiased analysis of diverse complex tissues.
Journal ArticleDOI
Development and Functional Diversification of Cortical Interneurons
TL;DR: An overview of the mechanisms underlying the generation of the distinct types of interneurons and their integration in cortical circuits is provided.
Journal ArticleDOI
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia.
TL;DR: Data from clinical studies suggesting that induction of frontal cortex gamma oscillations during tasks that engage cognitive or complex perceptual functions is attenuated in schizophrenia is reviewed.
References
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Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
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Phase relationship between hippocampal place units and the EEG theta rhythm
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TL;DR: The phase was highly correlated with spatial location and less well correlated with temporal aspects of behavior, such as the time after place field entry, and the characteristics of the phase shift constrain the models that define the construction of place fields.
Journal ArticleDOI
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
TL;DR: Optogenetics opens the door to a new kind of informational analysis of brain function, permitting quantitative delineation of the functional significance of individual elements in the emergent operation and function of intact neural circuitry.