Journal ArticleDOI
Feasibility of contrast-enhanced sonography during resection of cerebral tumours: initial results of a prospective study.
Martin Engelhardt,C. Hansen,Jens Eyding,Wilko Wilkening,Christopher Brenke,Christos Krogias,Martin Scholz,Albrecht Harders,Helmut Ermert,Kirsten Schmieder +9 more
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TLDR
Intraoperative contrast-enhanced ultrasonography enabled visualisation of cerebral tumours in high spatial resolution and tissue differentiation with contrast agent was superior to conventional B-mode ultrasound imaging.Abstract:
The aim of this study was to adapt the ultrasonographical techniques developed for brain perfusion imaging to an intraoperative setting for topographic diagnosis of cerebral tumours During surgery, the patients underwent contrast-enhanced ultrasonography (phase inversion harmonic imaging, bolus kinetic, fitted model function) Endocavity curved array (65EC10, 65 MHz) was used intraoperatively The ultrasound contrast agent SonoVue (Bracco) was administered IV as a bolus injection Off-line, time-intensity curves as well as perfusion maps were calculated and parameters such as peak intensity were locally extracted to characterise perfusion Seven patients with brain tumours of different histologic types were subjected to contrast-enhanced ultrasonography during surgery Tissue differentiation with contrast agent was superior to conventional B-mode ultrasound imaging Intraoperative contrast-enhanced ultrasonography enabled visualisation of cerebral tumours in high spatial resolutionread more
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The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)
Paul S. Sidhu,Vito Cantisani,Christoph F. Dietrich,Odd Helge Gilja,Adrian Saftoiu,Eva Bartels,Michele Bertolotto,Fabrizio Calliada,Dirk-André Clevert,David O. Cosgrove,Annamaria Deganello,Mirko D'Onofrio,Francesco Maria Drudi,Simon Freeman,Chris J Harvey,Christian Jenssen,Ernst Michael Jung,Andrea Klauser,Nathalie Lassau,Maria Franca Meloni,Edward Leen,Carlos Nicolau,Christian Pállson Nolsøe,Fabio Piscaglia,Francesco Prada,H. Prosch,Maija Radzina,Luca Savelli,Hans Peter Weskott,Hessel Wijkstra +29 more
TL;DR: The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.
Journal ArticleDOI
Intraoperative contrast-enhanced ultrasound for brain tumor surgery
Francesco Prada,Alessandro Perin,Alberto Martegani,Luca Aiani,Luigi Solbiati,Massimo Lamperti,Cecilia Casali,Federico G. Legnani,Luca Mattei,Andrea Saladino,Marco Saini,Francesco DiMeco +11 more
TL;DR: This study is the first large-scale implementation of i CEUS in neurosurgery as a dynamic and continuous real-time imaging tool for brain surgery and provides the first iCEUS characterization of different brain neoplasms.
Journal ArticleDOI
Applications of Ultrasound in the Resection of Brain Tumors
Rahul A. Sastry,Wenya Linda Bi,Steve Pieper,Sarah F. Frisken,Tina Kapur,William M. Wells,Alexandra J. Golby +6 more
TL;DR: The current state, potential, and challenges of intraoperative ultrasound for brain tumor resection are reviewed and opportunities for future directions in the development of ultrasound technologies are identified.
Journal ArticleDOI
Intraoperative cerebral glioma characterization with contrast enhanced ultrasound.
Francesco Prada,Luca Mattei,Massimiliano Del Bene,Luca Aiani,Marco Saini,Cecilia Casali,Assunta Filippini,Federico G. Legnani,Alessandro Perin,Andrea Saladino,Ignazio G. Vetrano,Luigi Solbiati,Alberto Martegani,Francesco DiMeco +13 more
TL;DR: This study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors' biology and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.
Journal ArticleDOI
Objective assessment of utility of intraoperative ultrasound in resection of central nervous system tumors: A cost-effective tool for intraoperative navigation in neurosurgery.
Aliasgar Moiyadi,Prakash Shetty +1 more
TL;DR: The IOUS is a very useful tool in intraoperative localization and delineation of lesions and planning various stages of tumor resection and should be increasingly used by neurosurgeons in the developing world where costlier intraoperative localized and imaging is not available freely.
References
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Journal ArticleDOI
Ultrasonographic detection of focal liver lesions: increased sensitivity and specificity with microbubble contrast agents.
TL;DR: In this field the use of US contrast agents appears to have advantages over formerly used non contrast-enhanced methods although no conclusive results are available yet.
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Correlation of intra-operative ultrasound with histopathologic findings after tumour resection in supratentorial gliomas. A method to improve gross total tumour resection.
TL;DR: It is concluded, that IOUS following resection of supratentorial gliomas can detect residual tumour tissue with high specificity and thus improve gross total resection, however, a thin hyperechoic rim surrounding the resection cavity is a non-specific finding, which can mask thin residual tumours layers and therefore needs further evaluation of its nature.
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Sequential visualization of brain and fiber tract deformation during intracranial surgery with three-dimensional ultrasound: an approach to evaluate the effect of brain shift.
Volker A. Coenen,Timo Krings,Jürgen Weidemann,Franz-Josef Hans,Peter C. Reinacher,Joachim M. Gilsbach,Veit Rohde +6 more
TL;DR: By definition and sequential intraoperative registration of ultrasound landmarks near the fiber tract, brain shift-associated deformation of a tract that is not visible sonographically can be assessed correctly and seems to help identify and avoid eloquent brain areas during intracranial surgery.
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Ultrasound contrast agents for brain perfusion imaging and ischemic stroke therapy
TL;DR: The current state of microbubbles technology and the use of contrast‐enhanced transcranial ultrasound for the assessment of brain perfusion is discussed and future aspects and expecta tions in contrast agent functionality, such as targeting and drug or gene delivery, acceleration of thrombolysis, and imaging technology, are discussed.
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History of intraoperative ultrasound in neurosurgery.
TL;DR: The use of real-time ultrasound to localize, characterize, and instrument lesions of the brain and spinal chord and the various applications of ultrasound in the neurosurgical operating room are discussed.