Journal ArticleDOI
Fiber-optic confocal microscopy using a spatial light modulator.
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TLDR
The novel SLM-based system is more optically efficient, achieves higher contrast, and has improved optical-sectioning capabilities compared with those of other proposed instruments for confocal microendoscopy.Abstract:
We present a novel fiber-optic confocal microscope in which the scanning operation is achieved by use of a spatial light modulator (SLM) to sequentially illuminate individual fibers or patterns of multiple fibers. Experimental images are presented, and the optical-sectioning capability of the device is demonstrated. The novel SLM-based system is more optically efficient, achieves higher contrast, and has improved optical-sectioning capabilities compared with those of other proposed instruments for confocal microendoscopy.read more
Citations
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Journal ArticleDOI
Fiber-optic fluorescence imaging.
Benjamin A. Flusberg,Eric D. Cocker,Wibool Piyawattanametha,Juergen C. Jung,Eunice L. M. Cheung,Mark J. Schnitzer +5 more
TL;DR: Two new classes of photonic crystal fiber facilitate ultrashort pulse delivery for fiber-optic two-photon fluorescence imaging and an upcoming generation of fluorescence Imaging devices will be based on microfabricated device components.
Journal ArticleDOI
Exploiting multimode waveguides for pure fibre-based imaging
Tomáš Čižmár,Kishan Dholakia +1 more
TL;DR: A novel approach is presented by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion and showing how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices.
Journal ArticleDOI
Multiphoton endoscopy: optical design and application to in vivo imaging of mammalian hippocampal neurons
TL;DR: This work introduces minimally invasive multiphoton fluorescence microendoscopes (350-1000 /spl mu/ in diameter) based on compound microlenses and demonstrates multipoton endoscopy in live animals by visualizing rodent hippocampal neurons and dendrites.
Journal ArticleDOI
Optical systems for in vivo molecular imaging of cancer.
Konstantin V Sokolov,Jesse Aaron,Betsy Hsu,Dawn L. Nida,Ann M. Gillenwater,Michele Follen,Calum MacAulay,Karen Adler-Storthz,Brian A. Korgel,Michael R. Descour,Renata Pasqualini,Wadih Arap,Wan L. Lam,Rebecca Richards-Kortum +13 more
TL;DR: A comprehensive strategy to develop inexpensive, rugged and portable optical imaging systems for molecular imaging of cancer, which couples the development of optically active contrast agents with advances in functional genomics of cancer.
Journal ArticleDOI
New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions
TL;DR: A enhancement of the endoscopist’s ability to detect subtle preneoplastic changes in the gastrointestional mucosa in real time and improved staging of lesions could lead to curative endoscopic ablation of these lesions and, in the long term, improve patient survival and quality of life.
References
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Proceedings ArticleDOI
Digital Light Processing for high-brightness, high-resolution applications
TL;DR: In this article, the authors describe the design, operation, performance, and advantages of DLP-based projection systems for high-brightness, high-resolution, and high resolution applications.
Journal ArticleDOI
Confocal microscopy through a fiber-optic imaging bundle
Arthur F. Gmitro,David J. Aziz +1 more
TL;DR: The concept for a new type of confocal microscope with a fiber-optic imaging bundle is presented, and experimental results are shown to demonstrate the principle.
Journal ArticleDOI
Size of the detector in confocal imaging systems.
Tony Wilson,A. R. Carlini +1 more
TL;DR: A criterion for detector size to give true confocal operation is introduced and it is shown that the lateral resolution is considerably more sensitive to detector size than is the depth-discrimination or optical-sectioning property.
Journal ArticleDOI
Micromachined scanning confocal optical microscope
TL;DR: A miniature confocal optical microscope for monochromatic imaging that uses single-mode fiber illumination and a two-phase off-axis zone plate objective lens and has 1.0-microm resolution over a 100- microm field of view is constructed.