Journal ArticleDOI
Fibroblast biology in three-dimensional collagen matrices.
TLDR
Research on fibroblast biology in three-dimensional collagen matrices offers new opportunities to understand the reciprocal and adaptive interactions that occur between cells and surrounding matrix in a tissue-like environment.About:
This article is published in Trends in Cell Biology.The article was published on 2003-05-01. It has received 826 citations till now. The article focuses on the topics: Tissue homeostasis & Fibroblast.read more
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Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
TL;DR: Although modern synthetic biomaterials represent oversimplified mimics of natural ECMs lacking the essential natural temporal and spatial complexity, a growing symbiosis of materials engineering and cell biology may ultimately result in synthetic materials that contain the necessary signals to recapitulate developmental processes in tissue- and organ-specific differentiation and morphogenesis.
Journal ArticleDOI
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
Judith Campisi,Judith Campisi +1 more
TL;DR: The senescence response may be antagonistically pleiotropic, promoting early-life survival by curtailing the development of cancer but eventually limiting longevity as dysfunctional senescent cells accumulate.
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Gold nanoparticles in biology: beyond toxicity to cellular imaging
Catherine J. Murphy,Anand Gole,John W. Stone,Patrick N. Sisco,Alaaldin M. Alkilany,Edie C. Goldsmith,Sarah C. Baxter +6 more
TL;DR: The importance of surface chemistry and cell type for interpretation of nanoparticle cytotoxicity studies is illustrated and a relatively unusual live cell application with gold nanorods is described.
Journal ArticleDOI
Modeling Tissue Morphogenesis and Cancer in 3D
Kenneth M. Yamada,Edna Cukierman +1 more
TL;DR: Three-dimensional (3D) in vitro models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors and may help to accelerate translational research in cancer biology and tissue engineering.
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Formation and Function of the Myofibroblast during Tissue Repair
TL;DR: Intervention with myofibroblast stress perception and transmission offers novel strategies to reduce tissue contracture; stress release leads to the instant loss of contraction and promotes apoptosis.
References
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Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis
Katarina Wolf,Irina B. Mazo,Harry Leung,Katharina Engelke,Ulrich H. von Andrian,Elena I. Deryugina,Alex Y. Strongin,Eva B. Bröcker,Peter Friedl +8 more
TL;DR: The transition from proteolytic mesenchymal toward nonproteolytic amoeboid movement highlights a supramolecular plasticity mechanism in cell migration and further represents a putative escape mechanism in tumor cell dissemination after abrogation of pericellular proteolysis.
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Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity
TL;DR: An increased alpha-SMA expression is sufficient to enhance fibroblast contractile activity, with the use of silicone substrates of different stiffness degrees.
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Fibroblasts, myofibroblasts, and wound contraction
TL;DR: A clinical case reconstructed by Guido Majno (1975) from the Hippocratic records describes a wrestler who visits the iatreion (out-patient clinic) to be treated for a shoulder dislocation, and a drastic measure of inducing wound contraction is adopted by poking a hot needle through the skin of the armpit.
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Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness
TL;DR: Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded with epidermal cells were successfully grafted onto the donors of the cells.