Finite Element Modeling of Mitral Valve Repair
Ashley E. Morgan,Joe Luis Pantoja,Jonathan W. Weinsaft,Eugene A. Grossi,Julius M. Guccione,Liang Ge,Mark B. Ratcliffe +6 more
TLDR
An overview of relevant mitral valve diseases is presented, the evolution of FE models of surgical valve repair techniques are described, and Computational modeling through finite element (FE) analysis is described.Abstract:
The mitral valve is a complex structure regulating forward flow of blood between the left atrium and left ventricle (LV). Multiple disease processes can affect its proper function, and when these diseases cause severe mitral regurgitation (MR), optimal treatment is repair of the native valve. The mitral valve (MV) is a dynamic structure with multiple components that have complex interactions. Computational modeling through finite element (FE) analysis is a valuable tool to delineate the biomechanical properties of the mitral valve and understand its diseases and their repairs. In this review, we present an overview of relevant mitral valve diseases, and describe the evolution of FE models of surgical valve repair techniques.read more
Citations
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Quantification and simulation of layer-specific mitral valve interstitial cells deformation under physiological loading
Chung-Hao Lee,Christopher A. Carruthers,Salma Ayoub,Robert C. Gorman,Joseph H. Gorman,Michael S. Sacks +5 more
TL;DR: This work quantified the in-situ layer-specific MVIC deformations for each of the four layers under a controlled biaxial tension loading device coupled to multi-photon microscopy and explored the interrelationship between the MVIC stiffness and deformation to layer- specific tissue mechanical and structural properties using a macro-micro finite element computational model.
Journal ArticleDOI
Preoperative planning with three-dimensional reconstruction of patient's anatomy, rapid prototyping and simulation for endoscopic mitral valve repair.
Peyman Sardari Nia,Samuel Heuts,Jean H.T. Daemen,Peter Luyten,Jindrich Vainer,Jan C.A. Hoorntje,Emile C. Cheriex,Jos G. Maessen +7 more
TL;DR: The patient-specific simulation and planning could be applied for surgical training, starting the (minimally invasive) mitral valve repair programme, planning of complex cases and the evaluation of new interventional techniques.
Journal ArticleDOI
Finite Element Analysis of Tricuspid Valve Deformation from Multi-slice Computed Tomography Images
Fanwei Kong,Thuy Pham,Caitlin Martin,Raymond G. McKay,Charles Primiano,Sabet Hashim,Susheel Kodali,Wei Sun +7 more
TL;DR: Finite element models of human TVs from multi-slice computed tomography images are developed to investigate chordal forces and leaflet stresses and strains and can serve as baseline biomechanical metrics of TV mechanics and may be used to inform TV repair device design.
Journal ArticleDOI
Development of a Functionally Equivalent Model of the Mitral Valve Chordae Tendineae Through Topology Optimization
Amir H. Khalighi,Bruno V. Rego,Andrew Drach,Robert C. Gorman,Joseph H. Gorman,Michael S. Sacks +5 more
TL;DR: This work showed that the closing behavior of complete MV apparatus under normal, diseased, and surgically repaired scenarios can be faithfully replicated by a functionally equivalent MVCT model comprised of two representative papillary muscle heads, single strand chords, and a uniform insertion distribution with a density of 15 insertions/cm2.
Journal Article
A high-fidelity and micro-anatomically accurate 3D finite element model for simulations of functional mitral valve
Chung-Hao Lee,Pim J A Oomen,Jean-Pierre Rabbah,Ajit P. Yoganathan,Robert C. Gorman,Joseph H. Gorman,Rouzbeh Amini,Michael S. Sacks +7 more
TL;DR: In this paper, a high-fidelity computational framework incorporating detailed collagen fiber architecture, accurate constitutive models for soft valve tissues, and micro-anatomically accurate valvular geometry, for simulations of functional mitral valves which allows us to investigate the organ-level mechanical responses due to physiological loadings.
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