Journal ArticleDOI
Formation of the ribosome-G factor-GDP complex in the presence of fusidic acid
TLDR
When ribosomes are incubated with G factor and GTP, a ribosome-G factor-GDP complex is formed and more complex is isolated in the presence of the antibiotic than in its absence.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1969-10-22. It has received 149 citations till now. The article focuses on the topics: Fusidic acid & GTP'.read more
Citations
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Journal ArticleDOI
The role of guanosine 5'-triphosphate in polypeptide chain elongation.
Journal ArticleDOI
Antibiotic resistance in Staphylococcus aureus. Current status and future prospects.
TL;DR: This review focuses on development of resistance to currently used antibiotics and examines future prospects for new antibiotics and informed use of drug combinations.
Journal ArticleDOI
Inhibitors of protein synthesis
TL;DR: This study will be concerned mainly with advances in the knowledge of the mode of action, selectivity, and specificity of inhibitors of protein synthesis over the last ten years.
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The A-Z of bacterial translation inhibitors.
TL;DR: This review endeavors to provide a comprehensive “post-ribosome structure” A–Z of the huge diversity of antibiotics that target the bacterial translation apparatus, with an emphasis on correlating the vast wealth of biochemical data with more recently available ribosome structures, in order to understand function.
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Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus
TL;DR: Fusidic acid resistance resulting from mutations in elongation factor G (EF‐G) of Staphylococcus aureus is associated with fitness costs during growth in vivo and in vitro, and the acquisition of secondary intragenic mutations may contribute to a stabilization of the resistant bacteria present in a bacterial population.
References
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Journal ArticleDOI
Ion-exchange chromatography of nucleotides on poly-(ethyleneimine)-cellulose thin layers☆
K. Randerath,E. Randerath +1 more
TL;DR: A great number of naturally occurring mononucleotides can be separated and identified by poly(ethyleneimine)-cellulose thin-layer chromatography by comparison with other present techniques for separating nucleotides.
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The interrelationship between guanosine triphosphatase and amino acid polymerization.
Yasutomi Nishizuka,Fritz Lipmann +1 more
TL;DR: The purified complement, the G factor of Nishizuka and Lipmann, and salt-washed ribosomes were, by themselves, virtually free of guanosine triphosphatase (GTPase) activity, and by saturation with one component, GTP hydrolysis was linearly dependent upon the amount added of the other.
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Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics
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Translation and translocation of defined RNA messengers
TL;DR: A purified system for protein synthesis, derived from Esherichia coli, makes use of small, synthetic mRNA's initiated by the fMet ‡ codon, AUG, followed by a sequence of 3, 6 or 9 uridylic acid residues, which direct the binding of fMet- and Phe-tRNA to ribosomes and the synthesis of the corresponding f Met-initiated di-, tri- and tetrapeptides.
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Association of fusidic acid sensitivity with G factor in a protein-synthesizing system.
TL;DR: The localization of fusidic acid sensitivity was further studied with respect to the ribosomes and G factor of drug-sensitive E. coli cells and those of resistant cells, and it was demonstrated that the fusido acid sensitivity is associated with G factor, but not with theribosomes.