Function and Solution Structure of Huwentoxin-IV, a Potent Neuronal Tetrodotoxin (TTX)-sensitive Sodium Channel Antagonist from Chinese Bird Spider Selenocosmia huwena
TLDR
After comparison with other toxins purified from the same species, it is convinced that the positively charged residues of loop IV (residues 25–29), especially residue Arg-26, must be crucial to its binding to the neuronal tetrodotoxin-sensitive voltage-gated sodium channel.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-12-06 and is currently open access. It has received 139 citations till now. The article focuses on the topics: Huwentoxin & Inhibitor cystine knot.read more
Citations
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The Na(V)1.7 sodium channel: from molecule to man.
Sulayman D. Dib-Hajj,Yang Yang,Yang Yang,Joel A. Black,Joel A. Black,Stephen G. Waxman,Stephen G. Waxman +6 more
TL;DR: Homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant NaV1.7 that causes pain.
Journal ArticleDOI
The roles of sodium channels in nociception: Implications for mechanisms of pain
TL;DR: The role of voltage-gated sodium channels in nociception may provide important insights into pain mechanisms as discussed by the authors, and they are critically important for electrogenesis and nerve impulse conduction and a target for important clinically relevant analgesics such as lidocaine.
Comprehensive review The roles of sodium channels in nociception: Implications for mechanisms of pain
TL;DR: Electrophysiological experiments indicate that recessive mutations in Na(v)1.7 that eliminate functional current can result in an apparent complete, and possibly specific, indifference to pain in humans, suggesting that isoform specific blockers could be very effective in treating pain.
Journal ArticleDOI
The Role of Voltage-Gated Sodium Channels in Pain Signaling
TL;DR: Given the poor efficacy of current analgesics, the selective expression of particular VGSCs in sensory neurons makes these attractive targets for drug discovery, and the increasing availability of gene sequencing and electrophysiological analysis of gene variants provides the opportunity to better target existing therapies in a personalized manner.
References
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PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Book
NMR of proteins and nucleic acids
TL;DR: The NMR Assignment Problem in Biopolymers, two-Dimensional NMR With Proteins and Nucleic Acids, and Sequence-Specific Resonance Assignments.
Book ChapterDOI
The anatomy and taxonomy of protein structure.
TL;DR: This chapter investigates the anatomy and taxonomy of protein structures, based on the results of three-dimensional X-ray crystallography of globular proteins.
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