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Functional bowel disorders and functional abdominal pain.

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TLDR
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.
Abstract
The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. The terminology was clarified and the diagnostic criteria and management recommendations were revised. A functional bowel disorder (FBD) is diagnosed by characteristic symptoms for at least 12 weeks during the preceding 12 months in the absence of a structural or biochemical explanation. The irritable bowel syndrome, functional abdominal bloating, functional constipation, and functional diarrhea are distinguished by symptom-based diagnostic criteria. Unspecified FBD lacks criteria for the other FBDs. Diagnostic testing is individualized, depending on patient age, primary symptom characteristics, and other clinical and laboratory features. Functional abdominal pain (FAP) is defined as either the FAP syndrome, which requires at least six months of pain with poor relation to gut function and loss of daily activities, or unspecified FAP, which lacks criteria for the FAP syndrome. An organic cause for the pain must be excluded, but aspects of the patient's pain behavior are of primary importance. Treatment of the FBDs relies upon confident diagnosis, explanation, and reassurance. Diet alteration, drug treatment, and psychotherapy may be beneficial, depending on the symptoms and psychological features.

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Journal ArticleDOI

Splitting irritable bowel syndrome: from original Rome to Rome II criteria.

TL;DR: Many subjects meeting original Rome criteria for IBS do not meet Rome II criteria: approximately one quarter of subjects do not have sufficient symptom duration or frequency to be diagnosed with IBS and almost half are now considered as having other (“major” or “minor”) FBD.
Journal ArticleDOI

Intestinal Permeability in Irritable Bowel Syndrome Patients: Effects of NSAIDs

TL;DR: NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents.
Journal ArticleDOI

Rationale for using serotonergic agents to treat irritable bowel syndrome.

TL;DR: The use of serotonergic agents in patients with IBS is based on the critical role that serotonin plays in the maintenance of normal gut function and brain-gut communication.
Journal ArticleDOI

The diagnosis of IBS in primary care: consensus development using nominal group technique

TL;DR: The basis of IBS diagnosis in primary care differs from, and is less exclusive than, existing criteria, while psychosocial features, patient characteristics and contextual factors are important in increasing diagnostic probability.
Journal ArticleDOI

Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial.

TL;DR: Tegaserod is effective in treating overall IBS symptoms in patients with IBS-Mixed and IBS with constipation and the most frequent adverse events leading to study discontinuation in tegaserod-treated patients were diarrhea and abdominal pain.
References
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Journal ArticleDOI

U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact.

TL;DR: Symptom reporting, except for incontinence, declines with age, and low income is associated with greater symptom reporting, and the rate of work/school absenteeism and physician visits is increased for those having a functional gastrointestinal disorder.
Journal ArticleDOI

Towards positive diagnosis of the irritable bowel

TL;DR: It is concluded that a careful history can increase diagnostic confidence and reduce the amount of investigation in many patients with chronic abdominal pain.
Journal ArticleDOI

Defecation frequency and timing, and stool form in the general population: a prospective study.

TL;DR: It is concluded that conventionally normal bowel function is enjoyed by less than half the population and that, in this aspect of human physiology, younger women are especially disadvantaged.
Journal ArticleDOI

Towards positive diagnosis of the irritable bowel.

S Pearson, +1 more
- 25 Nov 1978 - 
TL;DR: The prevention of cot deaths is dependent firstly on the recognition by parents of the significance of certain non-specific symptoms and on their decision to involve the primary care services, and secondly on the efficacy of medical intervention at this stage.
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