Functional bowel disorders and functional abdominal pain.
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TLDR
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.Abstract:
The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. The terminology was clarified and the diagnostic criteria and management recommendations were revised. A functional bowel disorder (FBD) is diagnosed by characteristic symptoms for at least 12 weeks during the preceding 12 months in the absence of a structural or biochemical explanation. The irritable bowel syndrome, functional abdominal bloating, functional constipation, and functional diarrhea are distinguished by symptom-based diagnostic criteria. Unspecified FBD lacks criteria for the other FBDs. Diagnostic testing is individualized, depending on patient age, primary symptom characteristics, and other clinical and laboratory features. Functional abdominal pain (FAP) is defined as either the FAP syndrome, which requires at least six months of pain with poor relation to gut function and loss of daily activities, or unspecified FAP, which lacks criteria for the FAP syndrome. An organic cause for the pain must be excluded, but aspects of the patient's pain behavior are of primary importance. Treatment of the FBDs relies upon confident diagnosis, explanation, and reassurance. Diet alteration, drug treatment, and psychotherapy may be beneficial, depending on the symptoms and psychological features.read more
Citations
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Journal ArticleDOI
Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation.
Carmen Alonso,Mar Guilarte,María Vicario,Laura Ramos,Ziad Ramadan,María Antolín,Cristina Martínez,Serge Rezzi,Esteban Saperas,Sunil Kochhar,Javier Santos,Juan R. Malagelada +11 more
TL;DR: Increased exposure to life events determines a defective jejunal epithelial response to incoming stimuli, which may represent an initial step in the development of prolonged mucosal dysfunction, and could be linked to enhanced susceptibility for IBS.
Journal ArticleDOI
Effects of A3309, an Ileal Bile Acid Transporter Inhibitor, on Colonic Transit and Symptoms in Females With Functional Constipation
Banny S. Wong,Michael Camilleri,Sanna McKinzie,Duane Burton,Hans Graffner,Alan R. Zinsmeister +5 more
TL;DR: A3309 accelerates colonic transit and loosens stool consistency in FC patients and significantly looser stool consistency was noted with both A3309 dosages compared with placebo.
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Long-term sensitization of primary afferents in adult rats exposed to neonatal colon pain
Chun Lin,Elie D. Al-Chaer +1 more
TL;DR: The results show that chronic visceral hypersensitivity is associated with peripheral sensitization, as well as central sensitization and TL visceral afferents projecting seem to be more involved in the processing of sensitized nociceptive input from the colon than acute nocICEptive input.
Journal ArticleDOI
Cross-talk and sensitization of bladder afferent nerves.
TL;DR: The coordination of pelvic physiologic function requires complex integrative sensory pathways that may converge both peripherally and/or centrally following a focal, acute irritative or infectious pelvic insult, and these same afferent pathways may produce generalized pelvic sensitization or cross‐sensitization as shown bi‐directionally for the bladder and bowel in an animal model.
Journal ArticleDOI
Pilot study on the effect of linaclotide in patients with chronic constipation.
Jeffrey M. Johnston,Caroline B. Kurtz,Douglas A. Drossman,Anthony Lembo,Brenda I. Jeglinski,James E. MacDougall,Stephen Antonelli,Mark G. Currie +7 more
TL;DR: In this pilot study, linaclotide treatment improved bowel habits and symptoms of patients with chronic constipation and clinical improvements were also demonstrated in abdominal discomfort, severity of constipation, and overall relief.
References
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Journal ArticleDOI
U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact.
Douglas A. Drossman,Zhiming Li,E Andruzzi,R D Temple,Nicholas J. Talley,W G Thompson,William E. Whitehead,J Janssens,Peter Funch-Jensen,E Corazziari +9 more
TL;DR: Symptom reporting, except for incontinence, declines with age, and low income is associated with greater symptom reporting, and the rate of work/school absenteeism and physician visits is increased for those having a functional gastrointestinal disorder.
Journal ArticleDOI
Towards positive diagnosis of the irritable bowel
TL;DR: It is concluded that a careful history can increase diagnostic confidence and reduce the amount of investigation in many patients with chronic abdominal pain.
Journal ArticleDOI
Defecation frequency and timing, and stool form in the general population: a prospective study.
TL;DR: It is concluded that conventionally normal bowel function is enjoyed by less than half the population and that, in this aspect of human physiology, younger women are especially disadvantaged.
Journal ArticleDOI
Towards positive diagnosis of the irritable bowel.
S Pearson,P Openshaw +1 more
TL;DR: The prevention of cot deaths is dependent firstly on the recognition by parents of the significance of certain non-specific symptoms and on their decision to involve the primary care services, and secondly on the efficacy of medical intervention at this stage.