Functional bowel disorders and functional abdominal pain.
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TLDR
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.Abstract:
The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. The terminology was clarified and the diagnostic criteria and management recommendations were revised. A functional bowel disorder (FBD) is diagnosed by characteristic symptoms for at least 12 weeks during the preceding 12 months in the absence of a structural or biochemical explanation. The irritable bowel syndrome, functional abdominal bloating, functional constipation, and functional diarrhea are distinguished by symptom-based diagnostic criteria. Unspecified FBD lacks criteria for the other FBDs. Diagnostic testing is individualized, depending on patient age, primary symptom characteristics, and other clinical and laboratory features. Functional abdominal pain (FAP) is defined as either the FAP syndrome, which requires at least six months of pain with poor relation to gut function and loss of daily activities, or unspecified FAP, which lacks criteria for the FAP syndrome. An organic cause for the pain must be excluded, but aspects of the patient's pain behavior are of primary importance. Treatment of the FBDs relies upon confident diagnosis, explanation, and reassurance. Diet alteration, drug treatment, and psychotherapy may be beneficial, depending on the symptoms and psychological features.read more
Citations
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Journal ArticleDOI
Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?
Timothy G. Dinan,Eamonn Martin Quigley,Salah M M Ahmed,Paul Scully,Sinead O'Brien,Liam O'Mahony,Siobhan M O'Mahony,Fergus Shanahan,P. W Napoleon Keeling +8 more
TL;DR: IBS is characterized by an overactivation of the hypothalamic-pituitary-adrenal axis and a proinflammatory cytokine increase.
Journal ArticleDOI
Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial
Michael Camilleri,Northcutt Allison Ruth,Steven Kong,George E. Dukes,David J. McSorley,Allen W. Mangel +5 more
TL;DR: Alosetron was well tolerated and clinically effective in alleviating pain and bowel-related symptoms in this population of women with IBS.
Journal ArticleDOI
Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices.
Jost Langhorst,Sigrid Elsenbruch,Julia Koelzer,Andreas Rueffer,Andreas Michalsen,Gustav Dobos +5 more
TL;DR: The fecal markers Lf, Cal, and PMN-e are able to differentiate active IBD from inactive IBD as well as from IBS and all three are superior to CRP in their diagnostic accuracy.
The Enteric Nervous System
TL;DR: The Enteric nervous system is a type of central nervous system that controls the action of the autonomic nervous systems in animals and humans.
Journal ArticleDOI
The IASP classification of chronic pain for ICD-11: Chronic primary pain
Michael K. Nicholas,Johan W.S. Vlaeyen,Johan W.S. Vlaeyen,Winfried Rief,Antonia Barke,Qasim Aziz,Rafael Benoliel,Milton Cohen,Stefan Evers,Maria Adele Giamberardino,Andreas Goebel,Beatrice Korwisi,Serge Perrot,Peter Svensson,Peter Svensson,Shuu Jiun Wang,Rolf-Detlef Treede,Rolf-Detlef Treede +17 more
TL;DR: The goal here is to create a classification that is useful in both primary care and specialized pain management settings for the development of individualized management plans, and to assist both clinicians and researchers by providing a more accurate description of each diagnostic category.
References
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