Functional bowel disorders and functional abdominal pain.
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TLDR
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.Abstract:
The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. The terminology was clarified and the diagnostic criteria and management recommendations were revised. A functional bowel disorder (FBD) is diagnosed by characteristic symptoms for at least 12 weeks during the preceding 12 months in the absence of a structural or biochemical explanation. The irritable bowel syndrome, functional abdominal bloating, functional constipation, and functional diarrhea are distinguished by symptom-based diagnostic criteria. Unspecified FBD lacks criteria for the other FBDs. Diagnostic testing is individualized, depending on patient age, primary symptom characteristics, and other clinical and laboratory features. Functional abdominal pain (FAP) is defined as either the FAP syndrome, which requires at least six months of pain with poor relation to gut function and loss of daily activities, or unspecified FAP, which lacks criteria for the FAP syndrome. An organic cause for the pain must be excluded, but aspects of the patient's pain behavior are of primary importance. Treatment of the FBDs relies upon confident diagnosis, explanation, and reassurance. Diet alteration, drug treatment, and psychotherapy may be beneficial, depending on the symptoms and psychological features.read more
Citations
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Analysis of the Gastrointestinal Symptoms of Uninvestigated Dyspepsia and Irritable Bowel Syndrome
TL;DR: The considerable overlap not only between UD and IBS, but also between GERD and Ibs, suggests the involvement of common pathophysiological disturbances in the two conditions.
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Effect of breadmaking process on in vitro gut microbiota parameters in irritable bowel syndrome
Adele Costabile,Sara Santarelli,Sandrine P. Claus,Jeremy D. Sanderson,Barry N. Hudspith,Jonathan Brostoff,Jane L. Ward,Alison Lovegrove,Peter R. Shewry,Hannah Jones,Andrew M. Whitley,Glenn R. Gibson +11 more
TL;DR: It is found that breads fermented by the traditional long fermentation and sourdough are less likely to lead to IBS symptoms compared to bread made using the Chorleywood Breadmaking Process.
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Hand-assisted laparoscopic total colectomy for slow transit constipation
Kevin C. W. Hsiao,Shu-Wen Jao,Chang-Chieh Wu,Tsai-Yu Lee,Huang-Jen Lai,Jung-Cheng Kang,Jung-Cheng Kang +6 more
TL;DR: Hand-assisted laparoscopic total colectomy with ileorectal anastomosis could be a safe and efficient technique in the treatment of STC.
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Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
Guo-Du Wang,Xiyu Wang,Sumei Liu,Mei-Hua Qu,Yun Xia,Bradley Needleman,Dean J. Mikami,Jackie D. Wood +7 more
TL;DR: The results support a hypothesis that afferent innervation of enteringic mast cells releases histamine and mast cell protease II, both of which are known to act in a diffuse paracrine manner to influence the behavior of enteric nervous system neurons and to elevate the sensitivity of spinal afferent terminals.
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Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus.
Christina Brock,Trine Andresen,Trine Andresen,Jens Brøndum Frøkjær,Jeremy D. Gale,Anne Estrup Olesen,Anne Estrup Olesen,Lars Arendt-Nielsen,Asbjørn Mohr Drewes,Asbjørn Mohr Drewes +9 more
TL;DR: Modality‐specific hyperalgesia was demonstrated in the lower gut following chemical sensitization of the oesophagus, reflecting widespread central hyperexcitability and a counterbalancing activation of descending inhibitory pathways.
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