Journal ArticleDOI
G0 is a major growth cone protein subject to regulation by GAP-43.
Stephen M. Strittmatter,Stephen M. Strittmatter,Dario Valenzuela,Dario Valenzuela,Timothy E. Kennedy,Eva J. Neer,Mark C. Fishman,Mark C. Fishman +7 more
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TLDR
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane and may be regulated by intracellular as well as extracellular signals.Abstract:
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.read more
Citations
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Journal ArticleDOI
Diversity of G proteins in signal transduction.
TL;DR: The heterotrimeric guanine nucleotide-binding proteins acting as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors generate the pathways that modulate cellular responses to complex chemical signals.
Journal ArticleDOI
Heterotrimeric C proteins: Organizers of transmembrane signals
TL;DR: Some features of the structure and function of mammalian G protein subunits are summarized, then how the elements of the cellular language may be ordered and weighted to allow the cell to respond properly to the message is discussed.
Journal ArticleDOI
GAP-43: an intrinsic determinant of neuronal development and plasticity.
TL;DR: In transgenic mice, overexpression of GAP-43 leads to the spontaneous formation of new synapses and enhanced sprouting after injury, and the protein might play an important role in mediating experience-dependent plasticity.
Journal ArticleDOI
Sequence alignment of the G-protein coupled receptor superfamily.
TL;DR: This work has compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.
Journal ArticleDOI
G Protein-Coupled Receptor Allosterism and Complexing
TL;DR: It is proposed that the study of allosteric phenomena will become of progressively greater import to the drug discovery process due to the advent of newer and more sensitive GPCR screening technologies.
References
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Journal ArticleDOI
G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
Journal ArticleDOI
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
TL;DR: The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described and the deduced amino acid sequences show 41 +/- 1 percent identity with rhodopsin.
Journal ArticleDOI
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain
TL;DR: The alpha subunit of GO was isolated without the use of ligands known to dissociate other G proteins, and should be of great utility in elucidating the mechanism of action of this family of GTP-binding proteins.
Journal ArticleDOI
Axonal growth-associated proteins.
TL;DR: The hypothesis that neuronal processes underlying more subtle aspects of axon growth and synaptogenesis may be down-regulated chronically in mature neurons is suggested.
Journal ArticleDOI
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
Meg Trahey,Frank McCormick +1 more
TL;DR: In Xenopus oocytes, this protein maintains normal p21 in a biologically inactive, GDP-bound state through its effect on GTPase activity, and it appears that the major effect of position 12 mutations is to prevent this protein from stimulating p21 GTP enzyme activity, thereby allowing these mutants to remain in the active GTP- bound state.
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