Journal ArticleDOI
Gallium-containing mesoporous bioactive glass with potent hemostatic activity and antibacterial efficacy
Sara Pourshahrestani,Ehsan Zeimaran,Nahrizul Adib Kadri,Nicola Gargiulo,Shani Samuel,Sangeetha Vasudevaraj Naveen,Tunku Kamarul,Mark R. Towler,Mark R. Towler +8 more
Reads0
Chats0
TLDR
It is demonstrated that the lowest Ga2O3-substituted MBG can be a potent candidate for controlling haemorrhage and wound infection.Abstract:
Haemorrhage remains the leading cause of potentially survivable death in both military and civilian populations. Although a large variety of hemostatic agents have been developed, many of them have an inadequate capacity to induce hemostasis and are not effective in killing bacteria. In recent years, mesoporous bioactive glasses (MBGs) were found to be effective in inducing hemostasis. However, the materials may not be considered as ideal hemostats since they do not offer antimicrobial activity. The gallium ion (Ga+3) not only exhibits antibacterial properties but also accelerates the blood coagulation cascade. The aim of this study was to develop MBGs containing various concentrations of Ga2O3 (1, 2 & 3 mol%) via the evaporation-induced self-assembly (EISA) process and investigate whether the addition of Ga3+ would induce both hemostatic and antibacterial effects. The results indicated that the incorporation of lower Ga2O3 content (1 mol%) into the MBG system improved structural properties including the specific surface area, mesopore size and pore volume as well as the release of silicon and calcium ions. The bioactive glass was found to stimulate blood coagulation, platelet adhesion and thrombus generation and exerted an antibacterial effect against both Escherichia coli and Staphylococcus aureus. Likewise, Ga-doped MBGs showed excellent cytocompatibility even after 3 days, with the 1% Ga2O3-containing MBG attaining the best biocompatibility that render them safe hemostatic agents for stopping bleeding. This study demonstrated that the lowest Ga2O3-substituted MBG can be a potent candidate for controlling haemorrhage and wound infection.read more
Citations
More filters
Journal ArticleDOI
Adsorption of heavy metals on functionalized-mesoporous silica: A review
TL;DR: In this paper, the main contributors in the development of heavy metals adsorbent have been summarized, focusing on the factors affecting the performance of the adsorbents such as support structural properties, functional groups chemical properties, and properties of the combined inorganic-organic structure.
Journal ArticleDOI
Chitosan-Based Composite Materials for Prospective Hemostatic Applications.
TL;DR: This review of chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers is provided to provide a reference for further research and development of effective hemostasis materials.
Journal ArticleDOI
Mesoporous bioactive glasses: Promising platforms for antibacterial strategies
Saeid Kargozar,Maziar Montazerian,Sepideh Hamzehlou,Sepideh Hamzehlou,Hae-Won Kim,Francesco Baino +5 more
TL;DR: This review summarizes the state of the art of MBGs in this field, highlighting the latest evolutions and the specific role played by metallic antimicrobial ions that can be incorporated in the glass composition and then properly released.
Journal ArticleDOI
Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications.
TL;DR: Key findings are that silica-based mesoporous BGs offer a potential alternative to the systemic delivery of antibiotics for prevention against infections and the composition dependent dissolution rate and the concentration of the doped elements affect the antibacterial efficacy of BGs.
Journal ArticleDOI
Mesoporous Silica-Based Materials with Bactericidal Properties
Andrea Bernardos,Elena Piacenza,Félix Sancenón,Mehrdad Hamidi,Aziz Maleki,Raymond J. Turner,Ramón Martínez-Máñez +6 more
TL;DR: This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections.
References
More filters
Journal ArticleDOI
Adsorption of Gases in Multimolecular Layers
Journal ArticleDOI
The Determination of Pore Volume and Area Distributions in Porous Substances. I. Computations from Nitrogen Isotherms
Journal ArticleDOI
The Bacterial Cell Envelope
TL;DR: The bacteria cell envelope is a complex multilayered structure that serves to protect these organisms from their unpredictable and often hostile environment.
Journal ArticleDOI
Thrombin signalling and protease-activated receptors
TL;DR: Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.
Journal ArticleDOI
Bioactive glass in tissue engineering
Mohamed N. Rahaman,Delbert E. Day,B. Sonny Bal,Qiang Fu,Steven B. Jung,Lynda F. Bonewald,Antoni P. Tomsia +6 more
TL;DR: Recent work has shown the ability of bioactive glass to promote angiogenesis, which is critical to numerous applications in tissue regeneration, such as neovascularization for bone regeneration and the healing of soft tissue wounds.