Journal ArticleDOI
Gene expression of thermosensitive TRP ion channels in the rat brain structures: Effect of adaptation to cold
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TLDR
Evidence is obtained that thermosensitive TRP ion channels can be involved in the mechanisms of thermal adaptation at the level of gene expression.About:
This article is published in Journal of Thermal Biology.The article was published on 2013-08-01. It has received 14 citations till now. The article focuses on the topics: Transient receptor potential channel & TRPV4.read more
Citations
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Journal ArticleDOI
Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
Purificación Ordás,Pablo Hernández-Ortego,Hugo Vara,Carlos Fernández-Peña,Alfonso Reimúndez,Cruz Morenilla-Palao,Ana Guadaño-Ferraz,Ana Gomis,Mark A. Hoon,Félix Viana,Rosa Señarís +10 more
TL;DR: It is shown that TRPM8 is also expressed in the central nervous system of the mouse brain, and the functional activity of this channel is confirmed using electrophysiological patch‐clamp recordings of septal neurons.
Journal ArticleDOI
Inherited stress-induced hypertension associates with altered gene expression of thermosensitive TRP ion channels in hypothalamus -
TL;DR: Assessment of the expression of thermosensitive TRP ion channel genes in functionally different parts of hypothalamus in normo- and hypertensive rats allows to come closer to understand the possible molecular bases of the status of hypertension and elucidate some aspects of the physiological role of the investigated thermossensitive TRp ion channels.
Journal ArticleDOI
Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling.
TL;DR: These findings attest to the presence of a functional relationship between TRP ion channels of the peripheral nervous system and TRP channels in the central structures of the brain.
Journal ArticleDOI
The Outwardly Rectifying Current of Layer 5 Neocortical Neurons that was Originally Identified as “Non-Specific Cationic” Is Essentially a Potassium Current
TL;DR: Fluorescence imaging of intracellular sodium and calcium indicators is used, and there is no evidence to suggest that it is associated with influx of either of these ions to the cell body or dendrites, suggesting that cesium-permeable delayed rectifier potassium channels generate this current.
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Involvement of neurogenomic regulation in maintenance of temperature homeostasis in the cold
T. V. Kozyreva,I. P. Voronova +1 more
TL;DR: Evidence is provided for the role of the rs11562975 single nucleotide polymorphism in the TRPM8 gene in the variability of temperature perception and, consequently, in the development of the cold defense response.
References
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Journal ArticleDOI
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.
Eva Mezey,Zsuzsanna Tóth,Daniel N. Cortright,Michelle K. Arzubi,James E. Krause,Robert Elde,Athena Guo,Peter M. Blumberg,Arpad Szallasi +8 more
TL;DR: The finding that VR1 is expressed not only in primary sensory neurons but also in several brain nuclei is of great importance in that it places VRs in a much broader perspective than pain perception.
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TRPA1 acts as a cold sensor in vitro and in vivo
Yuji Karashima,Karel Talavera,Wouter Everaerts,Annelies Janssens,Kelvin Y. Kwan,Rudi Vennekens,Bernd Nilius,Thomas Voets +7 more
TL;DR: It is concluded that TRPA1 acts as a major sensor for noxious cold, and a specific subset of cold-sensitive trigeminal ganglion neurons that is absent inTRPA1-deficient mice are identified.
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Transient receptor potential ion channels as participants in thermosensation and thermoregulation
TL;DR: The identification of invertebrate TRP channels, whose genetic ablation alters thermally driven behaviors, makes it clear that thermosensation represents an evolutionarily conserved role of this ion channel family.
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Lessons from peppers and peppermint: the molecular logic of thermosensation.
TL;DR: Analysis of TRP channel expression among sensory neurons is providing insight into how thermal stimuli are encoded by the peripheral nervous system, and how chemical signaling pathways, such as those activated by tissue injury, alter thermal sensitivity throughTRP channel modulation.