Journal ArticleDOI
Gene expression profiling analysis of deoxynivalenol-induced inhibition of mouse thymic epithelial cell proliferation.
Daotong Li,Yaqiong Ye,Li Deng,Haoran Ma,Xiaolong Fan,Yuan Zhang,Haikuo Yan,Xianbo Deng,Yugu Li,Yongjiang Ma +9 more
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TLDR
The results provide molecular insights into the gene expression differences of DON-induced toxic effects and suggest that p53 signaling pathway may play an important role in the inhibition of MTEC1 cell proliferation.About:
This article is published in Environmental Toxicology and Pharmacology.The article was published on 2013-09-01. It has received 14 citations till now. The article focuses on the topics: Gene expression profiling & Cell cycle.read more
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Journal ArticleDOI
Deoxynivalenol: signaling pathways and human exposure risk assessment--an update.
TL;DR: A human exposure risk assessment of DON from cereals, cereal-based foods, vegetables, water, and animal-derived foods in different countries and a review of global contamination with DON are conducted.
Journal ArticleDOI
Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach?
TL;DR: Research results concerning the role of gut microbiota in DON-induced immunotoxicity and gender differences are summarized to find some potential therapeutic strategies to tackle DON- induced immunot toxicity.
Journal ArticleDOI
Deoxynivalenol induces apoptosis in mouse thymic epithelial cells through mitochondria-mediated pathway.
Daotong Li,Haoran Ma,Yaqiong Ye,Changyun Ji,Xiaohong Tang,Dan Ouyang,Jian Chen,Yugu Li,Yongjiang Ma +8 more
TL;DR: It is suggested that DON causes the activation of p53, increased levels of ROS and the induction of mitochondrial dysfunction, which may contribute to DON-induced apoptosis in MTEC1 cells.
Journal ArticleDOI
The Antagonistic Effect of Mycotoxins Deoxynivalenol and Zearalenone on Metabolic Profiling in Serum and Liver of Mice.
Jian Ji,Pei Zhu,Fangchao Cui,Fangchao Cui,Fuwei Pi,Fuwei Pi,Yinzhi Zhang,Yinzhi Zhang,Yun Li,Jia-Sheng Wang,Jia-Sheng Wang,Xiulan Sun,Xiulan Sun +12 more
TL;DR: The metabolic pathway analysis demonstrated that the combined DON and ZEN treatment could down-regulate the valine, leucine and isoleucine biosynthesis, glycine, serine and threonine metabolism, and O-glycosyl compounds related glucose metabolism in liver tissue.
Journal ArticleDOI
Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells
Junmei Wang,Yongcheng Jin,Shunlu Wu,Hao Yu,Yun Zhao,Hengtong Fang,Jinglin Shen,Changhai Zhou,Yurong Fu,Ruihua Li,Rui Wang,Junxiong Wang,Kexin Zheng,Qingsong Fan,Bojiong Chen,Jing Zhang +15 more
TL;DR: In this article, the in vitro cytotoxicity of deoxynivalenol on bovine mammary epithelial cells (MAC-T) was investigated and it was shown that DON at different concentrations inhibited the growth of MAC-T cells after 24 hours of exposure (p <.001).
References
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Journal ArticleDOI
The first 30 years of p53: growing ever more complex
Arnold J. Levine,Moshe Oren +1 more
TL;DR: Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen, the oncoprotein of this tumour virus, and new functions of this protein were revealed, including the regulation of metabolic pathways and cytokines that are required for embryo implantation.
Journal ArticleDOI
Toxicology of deoxynivalenol (vomitoxin).
TL;DR: Deoxynivalenol (DON), a trichothecene, is prevalent worldwide in crops used for food and feed production, including in Canada and the United States and should be treated as an important food safety issue.
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Some major mycotoxins and their mycotoxicoses--an overview.
TL;DR: The determination of which of the many known mycotoxins are significant can be based upon their frequency of occurrence and/or the severity of the disease that they produce, especially if they are known to be carcinogenic.
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Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance.
TL;DR: A fusion of basic and translational research is needed to validate or refine existing risk assessments and regulatory standards for this common mycotoxin.
Journal ArticleDOI
Distinct roles for E2F proteins in cell growth control and apoptosis
TL;DR: It is concluded that E 2F family members play distinct roles in cell cycle control and that E2F1 may function as a specific signal for the initiation of an apoptosis pathway that must normally be blocked for a productive proliferation event.