Showing papers in "Environmental Toxicology and Pharmacology in 2013"

TL;DR: This review highlights the classification of nanoparticles giving special emphasis on biosynthesis of metal nanoparticle by viable organisms and the applications of these biosynthesized nanoparticles in a wide spectrum of potential areas of medical biology including catalysis, targeted drug delivery, cancer treatment, antibacterial agents and as biosensors.

TL;DR: The data so far available, both from in vivo and in vitro studies, indicate that this dietary polyphenol could be a promising agent in the field of cancer chemoprevention.

TL;DR: This review paper summarizes the current knowledge and brings latest research findings on the anticancer potential of this lytic peptide with diverse functions.

TL;DR: The molecular and cellular mechanisms involved in organ toxicity of phthalates are discussed; furthermore, pharmacokinetic, chemistry and the European regulation are summarized.

TL;DR: The effects of physicochemical properties of CNTs on toxicity and summarized the advances on the mechanism are evaluated and a set of recommendations for the advancement of understanding of the role of C NTs and future challenges in environmental and ecotoxicological research are recommended.

TL;DR: The toxicity associated with the nanoparticles and the advancement of "green" nanomaterials to resolve the toxicity issues are summarized.

TL;DR: Serous inflammation, severe hyperemia in alveoli, and edema were observed as pathological findings in the lung which suggest that the lung is the third target tissue of the ZnO nanoparticles.

TL;DR: Assessment of the sub-lethal effects of oxytetracycline and amoxicillin on zebrafish development and biomarkers indicated that physiological impairment in fish populations is unlike to occur, however, effects of chronic exposures to low doses of ABs must be investigated.

TL;DR: BaP is an epigenetic modifier for global and gene specific DNA methylation status in zebrafish larvae and does not change gene expression in cancer genes such as ras-association domain family member 1 (rassf1), telomerase reverse transcriptase (tert), c-jun, and c-myca.

TL;DR: Intraperitoneal administration of fucoxanthin significantly inhibited the growth of tumor mass in B16F10 cells implanted mice and in vivo in Balb/c mice.

TL;DR: It suggests that Fv/Fm, SOD and MDA were more sensitive than algal biomass, and M. aeruginosa showed stronger survivability than S. capriconutum.

TL;DR: The hematological and biochemical alterations led to the conclusion that the herbicide clomazone has toxic effects on the species P. lineatus, and that its presence in the environment may jeopardize the health of these animals.

TL;DR: It is necessary to elaborate the standard procedures and furtherly validate hair mineral analysis and deliver detailed methodology to provide meaningful reference ranges and take advantage of the potential that lies in Hair Mineral Analysis as a medical diagnostic technique.

TL;DR: Induction of oxidative stress in the blood and gill cells were evidenced by increased lipid peroxidation level, while antioxidants namely superoxide dismutase, catalase and glutathione reductase responded in a concentration-dependent manner.

TL;DR: Perinatal exposure of DBP could induce neurotoxicity in neonatal and immature offspring animals, but had no influence on mature animals after DBP withdrawal, which may provide basic experimental evidence for better understanding the neurotoxic effects ofDBP on neonatal, immature and mature brains.

TL;DR: There is a relationship between higher toxicity with longer carbon chain and a higher toxicity for sulfonic PFAAs than for carboxylic PFAas.

TL;DR: Investigation of the potential protective effect of cannabidiol against doxorubicin cardiotoxicity in rats revealed that it significantly reduced the expression of inducible nitric oxide synthase, nuclear factor-κB, Fas ligand and caspase-3, and increased theexpression of survivin in cardiac tissue of doxorbicin-treated rats.

TL;DR: The decrease in glycogen content and some histopathological changes were observed in liver after CPF exposure and co-administration of GSH can restore some of these alterations.

TL;DR: Results demonstrate inhibitory effect of dieckol compound on adipogenesis through the activation of the AMPK signal pathway.

TL;DR: The results indicated that imidacloprid has immunosuppressive effects at doses >5mg/kg, which could potentially be attributed to direct cytotoxic effects of IMD against T cells (particularly TH cells) and that long-term exposure could be detrimental to the immune system.

TL;DR: Impact of diclofenac on the mortality, growth, and development of fish, as well as the impact of the drug on histological changes and selected parameters of oxidative stress in the fish, are assessed.

TL;DR: Results of this study suggest that Bisphenol-A treatment impairs hepatic glucose oxidation and glycogen content through defective insulin signal transduction in liver of adult male albino rat.

TL;DR: T-2 toxin may induce the apoptosis in rat granulosa cells through oxidative stress, and these data suggest that T-2 toxins could be significantly inhibited through the use of antioxidant Trolox.

TL;DR: Results indicated that sulfonamides caused obvious toxic effects on spontaneous movements, heartbeats and hatching of t embryos, and also resulted in malformations in embryos and larvae.

TL;DR: The results suggest that quercetin potentially augmented the cardioprotective effect of losartan against chronic DOX cardiotoxicity via its antioxidant and anti-inflammatory properties.

TL;DR: The hypothesis that pyrethroid exposure may reduce host defenses against infection and cancer, particularly in subjects with impaired immune capacity is supported, as well as the ability of αCYP to reduce proinflammatory cytokine levels in an exposed healthy human population.

TL;DR: Pretreatment of hydroalcoholic extract of Black grapes to lead exposed rats significantly ameliorated lead-induced oxidative stress in tissues and produced improvement in hematological parameters over lead-exposed rats, indicating the beneficial role of Black grape to counteract the lead- induced oxidative stress.

TL;DR: It is suggested that GSPE has protective effect against renal oxidative damage induced by Cd, which provide a potential natural chemopreventive agent against Cd-poisoning.

TL;DR: The aim of this work was to analyze the biotoxicity produced by L-BMAA in vivo in rats, trying to elucidate its physiopathological mechanisms and to search for analogies between the found effects and pathologies like Amyotrophic Lateral Sclerosis.

TL;DR: Findings suggest that differential effects and mechanisms of NaAsO₂ and As ₂O⁃ may responsible for the paradoxical effects of arsenic on the carcinogenesis and anticancer function.