Journal ArticleDOI
Genome-wide association study for mandibular prognathism using microsatellite and pooled DNA method.
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TLDR
The genome‐wide association study using microsatellites suggested that 6 loci (1p22.3, 1q32.2, 3q23, 6q23.22, and 15q22.22) were susceptibility regions of mandibular prognathism.About:
This article is published in American Journal of Orthodontics and Dentofacial Orthopedics.The article was published on 2017-09-01. It has received 20 citations till now. The article focuses on the topics: Microsatellite & Locus (genetics).read more
Citations
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Exclusion of Class III malocclusion candidate loci in Brazilian families
R. M. Cruz,James K. Hartsfield,James K. Hartsfield,G. Falcão-Alencar,D. L. Koller,Rinaldo Wellerson Pereira,James Mah,Iris Ferrari,Silviene Fabiana de Oliveira +8 more
TL;DR: The role played by genetic components in the etiology of the Class III phenotype, a class of dental malocclusion, is not yet understood as mentioned in this paper, and there is a dependency of the genetic background of the population in linkage studies.
Journal ArticleDOI
Genetic factors contributing to skeletal class III malocclusion: a systematic review and meta-analysis.
TL;DR: In this paper, the authors report and critically assess the findings of the available scientific evidence from genetic association studies examining the genetic variants underlying skeletal class III malocclusion and its sub-phenotypes.
Journal ArticleDOI
Orthodontics and Genetics.
TL;DR: The inheritance of malocclusions is described, highlighting the areas of knowledge where research has explored mechanisms that explain deviations in patterns of craniofacial growth.
Journal ArticleDOI
Whole-exome sequencing in a Japanese pedigree implicates a rare non-synonymous single-nucleotide variant in BEST3 as a candidate for mandibular prognathism.
TL;DR: In this article, a whole-exome sequencing was conducted to explore variants related to mandibular prognathism in a Japanese pedigree, and a rare non-synonymous single-nucleotide variants (SNVs) of UBASH3B, OR6M1, OR8D4, or8B4, and BEST3 genes were detected in all 4 affected individuals, but in none of the 5 unaffected individuals.
References
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Journal ArticleDOI
GENEPOP (Version 1.2): Population Genetics Software for Exact Tests and Ecumenicism
Michel Raymond,François Rousset +1 more
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The Future of Genetic Studies of Complex Human Diseases
TL;DR: The identification of the genetic basis of complex human diseases such as schizophrenia and diabetes has proven difficult as mentioned in this paper, and Risch and Merikangas proposed that they can best accomplish this goal by combining the power of the human genome project with association studies.
Journal ArticleDOI
Targeted capture and massively parallel sequencing of 12 human exomes
Sarah B H Ng,Emily H. Turner,Peggy D. Robertson,Steven D. Flygare,Abigail W. Bigham,Choli Lee,Tristan Shaffer,Michelle Wong,Arindam Bhattacharjee,Evan E. Eichler,Michael J. Bamshad,Deborah A. Nickerson,Jay Shendure +12 more
TL;DR: It is shown that candidate genes for Mendelian disorders can be identified by exome sequencing of a small number of unrelated, affected individuals, and may be extendable to diseases with more complex genetics through larger sample sizes and appropriate weighting of non-synonymous variants by predicted functional impact.
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Prediction of mandibular growth rotation
TL;DR: A structural method is described by which it may be possible to predict, from a single cephalogram, the course of rotation, where this feature is marked, and is based on information gained from implant studies of the remodeling process of the mandible during growth.
Journal ArticleDOI
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.
Alexandra Zhernakova,E Festen,Lude Franke,Lude Franke,Gosia Trynka,Cleo C. van Diemen,Alienke J. Monsuur,Marianna Bevova,Rian M. Nijmeijer,Ruben van 't Slot,Roel Heijmans,H. Marike Boezen,David A. van Heel,Adriaan A. van Bodegraven,Pieter C. F. Stokkers,Cisca Wijmenga,Cisca Wijmenga,J. Bart A. Crusius,Rinse K. Weersma +18 more
TL;DR: The results indicate two IBD loci and further support the importance of the innate immune system in the predisposition to both CD and UC.