Journal ArticleDOI
Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii sp. nov. (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU).
Alexandr Nemec,Lenka Krizova,Martina Maixnerova,Tanny J. K. van der Reijden,Pieter Deschaght,Virginie Passet,Mario Vaneechoutte,Sylvain Brisse,Lenie Dijkshoorn +8 more
TLDR
The genomic distinctness and monophyly of the individual species of the Acinetobacter baumannii complex were supported and some degree of differentiation between them could be made on the basis of growth at different temperatures and of assimilation of malonate, l-tartrate levulinate or citraconate.About:
This article is published in Research in Microbiology.The article was published on 2011-05-01. It has received 302 citations till now. The article focuses on the topics: Acinetobacter nosocomialis & Acinetobacter pittii.read more
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Uncovering the mechanisms of Acinetobacter baumannii virulence.
TL;DR: The molecular features that promote environmental persistence, including desiccation resistance, biofilm formation and motility, and the most recently identified virulence factors, such as secretion systems, surface glycoconjugates and micronutrient acquisition systems that collectively enable these pathogens to successfully infect their hosts are explored.
Journal ArticleDOI
Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models
TL;DR: This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition.
Journal ArticleDOI
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
TL;DR: The pathogenesis of the infections caused by this microorganism as well as the molecular bases of antibacterial resistance and clinical aspects such as treatment and potential future therapeutic strategies are discussed in depth.
Journal ArticleDOI
The Genomic Diversification of the Whole Acinetobacter Genus: Origins, Mechanisms, and Consequences
Marie Touchon,Jean Cury,Jean Cury,Eun-Jeong Yoon,Lenka Krizova,Gustavo C. Cerqueira,Cheryl I. Murphy,Michael Feldgarden,Jennifer R. Wortman,Dominique Clermont,Thierry Lambert,Catherine Grillot-Courvalin,Alexandr Nemec,Patrice Courvalin,Eduardo P. C. Rocha +14 more
TL;DR: The data suggest that A. baumannii arose from an ancient population bottleneck followed by population expansion under strong purifying selection, and the outstanding diversification of the species occurred largely by horizontal transfer at specific hotspots preferentially located close to the replication terminus.
Journal ArticleDOI
Defining bacterial species in the genomic era: insights from the genus Acinetobacter.
Jacqueline Z.-M. Chan,Mihail R. Halachev,Nicholas J. Loman,Chrystala Constantinidou,Mark J. Pallen +4 more
TL;DR: A combination of core genome phylogenetic analysis and ANI provides an appropriate method for bacterial species delineation, whereby bacterial species are defined as monophyletic groups of isolates with genomes that exhibit at least 95% pair-wise ANI.
References
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MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
TL;DR: Version 4 of MEGA software expands on the existing facilities for editing DNA sequence data from autosequencers, mining Web-databases, performing automatic and manual sequence alignment, analyzing sequence alignments to estimate evolutionary distances, inferring phylogenetic trees, and testing evolutionary hypotheses.
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Genomic insights that advance the species definition for prokaryotes
TL;DR: The average nucleotide identity of the shared genes between two strains was found to be a robust means to compare genetic relatedness among strains, and that ANI values of approximately 94% corresponded to the traditional 70% DNA-DNA reassociation standard of the current species definition.
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An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii.
TL;DR: An overview of the current knowledge of the genus Acinetobacter is presented, with the emphasis on the clinically most important species, Acetobacter baumannii.
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Taxonomy of the genus Acinetobacter with the recognition of Acinetobacter baumannii sp. nov., Acinetobacter haemolyticus sp. nov., Acinetobacter johnsonii sp. nov., and Acinetobacter junii sp. nov. and emended descriptions of Acinetobacter calcoaceticus and Acinetobacter lwoffii
TL;DR: Using deoxyribonucleic acid hybridization (S1 nuclease method), 12 hybridization groups (genospecies) containing 74 strains among 85 Acinetobacter strains studied could be unambiguously identified.