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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

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TLDR
It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Abstract
Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is the fourth leading cause of chronic morbidity and mortality in the United States, and is projected to rank fifth in 2020 in burden of disease worldwide, according to a study published by the World Bank/World Health Organization. Yet, COPD remains relatively unknown or ignored by the public as well as public health and government officials. In 1998, in an effort to bring more attention to COPD, its management, and its prevention, a committed group of scientists encouraged the U.S. National Heart, Lung, and Blood Institute and the World Health Organization to form the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Among the important objectives of GOLD are to increase awareness of COPD and to help the millions of people who suffer from this disease and die prematurely of it or its complications. The first step in the GOLD program was to prepare a consensus report, Global Strategy for the Diagnosis, Management, and Prevention of COPD, published in 2001. The present, newly revised document follows the same format as the original consensus report, but has been updated to reflect the many publications on COPD that have appeared. GOLD national leaders, a network of international experts, have initiated investigations of the causes and prevalence of COPD in their countries, and developed innovative approaches for the dissemination and implementation of COPD management guidelines. We appreciate the enormous amount of work the GOLD national leaders have done on behalf of their patients with COPD. Despite the achievements in the 5 years since the GOLD report was originally published, considerable additional work is ahead of us if we are to control this major public health problem. The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary.

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References
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Journal ArticleDOI

Randomized Controlled Trial of Dietary Creatine as an Adjunct Therapy to Physical Training in Chronic Obstructive Pulmonary Disease

TL;DR: This adequately powered, randomized, placebo-controlled trial shows that CrS does not augment the substantial training effect of multidisciplinary PR for patients with COPD.
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The Role of Infection in COPD

TL;DR: About half of exacerbations of COPD involve bacterial infection, but patients are not easy to differentiate from those who are uninfected, which means that antibiotics have to be given more often than is strictly necessary.
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Small airway pathology is related to increased closing capacity and abnormal slope of phase III in excised human lungs.

TL;DR: Single-breath nitrogen and static pressure-volume curves were obtained from 29 excised human lungs and Mural inflammation and squamous metaplasia were 2 lesions of the small airways that differed significantly in degree between the 2 groups.
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Detecting chronic obstructive pulmonary disease using peak flow rate: cross sectional survey

TL;DR: How useful peak expiratory flow rate is for detecting people with chronic obstructive pulmonary disease in the community is investigated from the third national health and nutrition survey (NHANES III).
Journal ArticleDOI

FEV1 Decline in Patients with Chronic Obstructive Pulmonary Disease Associated with Biomass Exposure

TL;DR: In the biomass exposure COPD group the rate of FEV1 decline is slower and shows a more homogeneous rate of decline over time in comparison with smokers, a rare feature of biomass-induced airflow limitation.
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