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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

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TLDR
It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Abstract
Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is the fourth leading cause of chronic morbidity and mortality in the United States, and is projected to rank fifth in 2020 in burden of disease worldwide, according to a study published by the World Bank/World Health Organization. Yet, COPD remains relatively unknown or ignored by the public as well as public health and government officials. In 1998, in an effort to bring more attention to COPD, its management, and its prevention, a committed group of scientists encouraged the U.S. National Heart, Lung, and Blood Institute and the World Health Organization to form the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Among the important objectives of GOLD are to increase awareness of COPD and to help the millions of people who suffer from this disease and die prematurely of it or its complications. The first step in the GOLD program was to prepare a consensus report, Global Strategy for the Diagnosis, Management, and Prevention of COPD, published in 2001. The present, newly revised document follows the same format as the original consensus report, but has been updated to reflect the many publications on COPD that have appeared. GOLD national leaders, a network of international experts, have initiated investigations of the causes and prevalence of COPD in their countries, and developed innovative approaches for the dissemination and implementation of COPD management guidelines. We appreciate the enormous amount of work the GOLD national leaders have done on behalf of their patients with COPD. Despite the achievements in the 5 years since the GOLD report was originally published, considerable additional work is ahead of us if we are to control this major public health problem. The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary.

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References
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Journal ArticleDOI

Positive benefits of theophylline in a randomized, double-blind, parallel-group, placebo-controlled study of low-dose, slow-release theophylline in the treatment of COPD for 1 year.

TL;DR: Evaluated low‐dose, slow‐release oral theophylline administered over a 1‐year period in patients with COPD found to have anti‐inflammatory benefits and is safe in the treatment of COPD.
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Nocturnal noninvasive positive pressure ventilation in stable COPD : A systematic review and individual patient data meta-analysis

TL;DR: There is insufficient evidence to support the application of routine NIPPV in patients with stable COPD, however, higher IPAP levels, better compliance and higher baseline PaCO2 seem to improve Pa CO2.
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Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study.

TL;DR: In this paper, the authors conducted a study to demonstrate that therapy with oral prednisolone was not inferior to therapy with IV prednisolate using a double-blind, double-dummy design.
Journal ArticleDOI

Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.

TL;DR: It is suggested that PR3 may play a role in the hypersecretory process that is characteristic of CF, and its activity, as assessed by SLPI-resistant serine proteinase activity, correlated highly with its antigenic concentration measured by ELISA.
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