Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis.
Christopher N. Herndon,Lusine Aghajanova,Shaina Balayan,David W. Erikson,Fatima Barragan,Gabriel Goldfien,Kim Chi Vo,Shannon M. Hawkins,Linda C. Giudice +8 more
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TLDR
The eutopic endometrium in patients with adenomyosis has fundamental abnormalities that may predispose to invasion and survival beyond the myometrial interface.Abstract:
Objective:Adenomyosis is a clinical disorder defined by the presence of endometrial glands and stroma within the myometrium, the pathogenesis of which is poorly understood. We postulate that dysreg...read more
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Pathogenesis of endometriosis: the genetic/epigenetic theory
Philippe R. Koninckx,Anastasia Ussia,Leila Adamyan,Arnaud Wattiez,Victor Gomel,Dan C. Martin +5 more
TL;DR: The genetic epigenetic theory is compatible with all observations on endometriosis and a polygenetic/polyepigenetic mechanism is proposed to explain the hereditary aspects, the predisposition, and the endometiosis-associated changes in theendometrium, immunology, and placentation.
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Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics.
Soriful Islam,Soriful Islam,Andrea Ciavattini,Felice Petraglia,Mario Castellucci,Pasquapina Ciarmela +5 more
TL;DR: It is proposed that ECM should be considered as a crucial target for future therapeutics to control abnormal leiomyoma growth and associated clinical symptoms and the introduction of drugs that are specifically antifibrotic could be a good solution.
Journal ArticleDOI
Pathogenesis of adenomyosis: an update on molecular mechanisms.
Silvia Vannuccini,Claudia Tosti,Francisco Carmona,S. Joseph Huang,S. Joseph Huang,Charles Chapron,Sun-Wei Guo,Felice Petraglia +7 more
TL;DR: This work summarizes the key mediators of pain, abnormal uterine bleeding and infertility in adenomyosis, including sex steroid hormone receptors, inflammatory molecules, extracellular matrix enzymes, growth factors and neuroangiogenic factors.
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Physiology of the Endometrium and Regulation of Menstruation.
TL;DR: The endometrium is a prime target tissue for selective progesterone receptor modulators (SPRMs) and has therapeutic potential for the clinical unmet need of HMB, highlighting the crucial need for understanding mechanisms underpinning menstruation and its aberrations.
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Pathogenesis of deep endometriosis.
TL;DR: In conclusion the pathophysiology of deep endometriosis remains debated and the mechanisms of disease progression, as well as the role of genetics and epigenetics in the process, still needs to be unraveled.
References
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Journal ArticleDOI
Dating the endometrial biopsy.
TL;DR: It is asserted that examination of the endometrium during the secretory phase yields more information about the time of ovulation degree of progestational change and normality of theendometrium than any other test used in sterility studies.
Journal ArticleDOI
mTOR and cancer: insights into a complex relationship.
TL;DR: The rationale for the use of drugs that target mTOR, the unexpectedly complex mechanism of action of existing mTOR inhibitors and the potential benefits of developing drugs that function through different mechanisms are discussed.
Journal ArticleDOI
Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
Michelle Nisolle,Jacques Donnez +1 more
TL;DR: Peritoneal, ovarian and rectovaginal endometriotic lesions must be considered as three separate entities with different pathogeneses with a close relation with their mesodermal müllerian origin.
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Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility
L.C. Kao,Ariane Germeyer,Suzana Tulac,Shalini C Lobo,J. P. Yang,Robert N. Taylor,Kevin G. Osteen,Bruce A. Lessey,Linda C. Giudice +8 more
TL;DR: The data support dysregulation of select genes leading to an inhospitable environment for implantation, including genes involved in embryonic attachment, embryo toxicity, immune dysfunction, and apoptotic responses, as well as genes likely contributing to the pathogenesis of endometriosis, including aromatase, progesterone receptor, angiogenic factors, and others.
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Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis
Richard O. Burney,Said Talbi,A.E. Hamilton,Kim Chi Vo,Mette Nyegaard,Camran Nezhat,Bruce A. Lessey,Linda C. Giudice +7 more
TL;DR: Global gene expression analysis of endometrium from women with and without moderate/severe stage endometriosis and compared the gene expression signatures across various phases of the menstrual cycle provided a framework for further investigations on causality and mechanisms underlying attenuated progesterone response inendometrium of women with endometRIosis.