Journal ArticleDOI
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
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TLDR
The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.Abstract:
The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at the outer leaflet of the plasma membrane bilayer, although this assumption is based only on experiments with surface-labeling by galactose oxidase-NaB[3H]4 of intact and lysed erythrocyte membranes and inside-out vesicles.(9,10) Obviously, further extensive studies of the organization of glycolipid in other eukaryotic cell membranes are necessary. Interestingly, the majority of neutral glycolipids present in plasma membranes are cryptic (see Section 4.2.1).read more
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Journal ArticleDOI
Up-regulation of Neutral Glycosphingolipid Synthesis upon Long Term Inhibition of Ceramide Synthesis by Fumonisin B1
TL;DR: Analysis of SL and GSL synthesis in cultured cells using [4,5-3H]sphinganine as a metabolic precursor demonstrated that at low substrate concentrations, Gb3 synthesis is favored over GM3 synthesis and glucosylceramide synthesis isavored over sphingomyelin synthesis, whereas the opposite is true at high substrate concentrations.
Book ChapterDOI
Chapter 15 - Glycosphingolipids as Effectors of Growth and Differentiation
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Neutral and ionic alkylglucopyranosides. Synthesis, characterization and properties
TL;DR: In this paper, neutral and ionic α- and β- d -alkylglucopyranosides bearing hydrocarbon chains of different length (C 8 -C 16) were obtained via tosylates as intermediates.
Journal ArticleDOI
Homeostasis of cell-surface glycosphingolipid content in B16 melanoma cells: Evidence revealed by an endoglycoceramidase
TL;DR: This finding demonstrates a novel form of homeostatic regulation coupled to the GSL-synthesizing system in mammalian cells for maintaining the contents of both cell-surface GSLs and free ceramide.
Journal ArticleDOI
Gangliosides derived from a T cell lymphoma inhibit bone marrow cell proliferation and differentiation.
TL;DR: In vivo or in vitro treatment of bone marrow cells (BMC) with gangliosides of DL (DLG) results in inhibition of proliferative ability and alteration of colony-forming ability (CFA) of BMC.
References
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Journal ArticleDOI
Fibronectins—adhesive glycoproteins of cell surface and blood
Kenneth M. Yamada,Kenneth Olden +1 more
TL;DR: A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids.
Journal ArticleDOI
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
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