Journal ArticleDOI
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
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TLDR
The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.Abstract:
The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at the outer leaflet of the plasma membrane bilayer, although this assumption is based only on experiments with surface-labeling by galactose oxidase-NaB[3H]4 of intact and lysed erythrocyte membranes and inside-out vesicles.(9,10) Obviously, further extensive studies of the organization of glycolipid in other eukaryotic cell membranes are necessary. Interestingly, the majority of neutral glycolipids present in plasma membranes are cryptic (see Section 4.2.1).read more
Citations
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Modes of shedding of glycosphingolipids from mouse lymphoma cells.
W W Young,C A Borgman,D M Wolock +2 more
TL;DR: Two forms in which glycolipids are released from cell membranes are suggested: the first is in a large complex, possibly a membrane vesicle, which retains the Glycolipid profile of the membrane of intact cells while the second appears to result from the preferential release of particular glycolIPid components.
Journal ArticleDOI
Milk fat globule membrane – a source of polar lipids for colon health? A review
TL;DR: With knowledge on the potential health benefits of MFGM lipids and proteins, dairy industries could in the future address their research in developing new functional dairy products enriched in beneficial MFGM components.
Journal ArticleDOI
Circulating levels of ganglioside GM3 in metabolic syndrome: A pilot study.
Takashige Sato,Takashige Sato,Yutaka Nihei,Masakazu Nagafuku,Seiichi Tagami,Rina Chin,Mitsunobu Kawamura,Shigeru Miyazaki,Makoto Suzuki,Shu-ichi Sugahara,Yasuyuki Takahashi,Atsuko Saito,Yasuyuki Igarashi,Jin-ichi Inokuchi +13 more
TL;DR: Serum GM3 levels was affected by glucose and lipid metabolism abnormalities and by visceral obesity, and may be a useful marker for severity of metabolic syndrome.
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Synthesis of the H-disaccharide (2-O-α-l-fucopyranosyl-d-galactose) via the trichloroacetimidate method
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A flagellar surface glycoprotein mediating cell-substrate interaction in Chlamydomonas.
TL;DR: The results suggest this high-molecular-weight glycoprotein as a major candidate for the surface-exposed adhesive component that directly interacts with the substrate and couples the substrate to a system of force transduction presumed to be located within the flagellum.
References
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Fibronectins—adhesive glycoproteins of cell surface and blood
Kenneth M. Yamada,Kenneth Olden +1 more
TL;DR: A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids.
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Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
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