Journal ArticleDOI
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
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TLDR
The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.Abstract:
The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at the outer leaflet of the plasma membrane bilayer, although this assumption is based only on experiments with surface-labeling by galactose oxidase-NaB[3H]4 of intact and lysed erythrocyte membranes and inside-out vesicles.(9,10) Obviously, further extensive studies of the organization of glycolipid in other eukaryotic cell membranes are necessary. Interestingly, the majority of neutral glycolipids present in plasma membranes are cryptic (see Section 4.2.1).read more
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A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.
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TL;DR: Two monoclonal antibodies produced by hybridomas obtained from a mouse immunized with a colorectal carcinoma cell line bind specifically to human gastrointestinal cancer cells.
References
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Journal ArticleDOI
Composition and synthesis of gangliosides in rat hepatocyte and hepatoma cell lines.
TL;DR: The composition of gangliosides and their synthesis in a chemically-induced rat hepatoma cell line differ from the composition and synthesis seen in a nontumorigenic rat hepatocyte cell line, and the change resembles the altered pattern of gang liosides which occurs in mouse cell lines after transformation with oncogenic DNA viruses.
Journal Article
Inhibition of the lectin-induced mitogenic response of thymocytes by glycolipids.
TL;DR: Exogenous gangliosides at concentrations found in serum inhibit the concanavalin A- (Con A) induced mitogenic response of mouse thymocytes, and it is suggested that gangs shed by tumor cells could be involved in the generalized immunosuppression observed in such animals.
Journal Article
Association of the Glycolipid Pattern with Antigenic Alterations in Mouse Fibroblasts Transformed by Murine Sarcoma Virus
TL;DR: The potential usefulness of glycolipids as tumor-associated cell surface markers is demonstrated by immunofluorescence and labeling with galactose oxidase: NaB3H4 and immunization of rabbits with 3T3KiMSV cells but not with3T3 cells resulted in antibody production against asialo GM2.
Journal ArticleDOI
The Disialosyl Group of Glycoproteins: Occurrence in Different Tissues and Cellular Membranes
TL;DR: The disialosyl groups were enriched in glycoproteins of the membranous fractions of liver and brain, whereas only small amounts were observed in the soluble fractions, and the highest proportion of 8-O-substituted neuraminic acid was observed in glycopeptides of the plasma membrane fraction of the young rat brain.