Journal ArticleDOI
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
Reads0
Chats0
TLDR
The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.Abstract:
The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at the outer leaflet of the plasma membrane bilayer, although this assumption is based only on experiments with surface-labeling by galactose oxidase-NaB[3H]4 of intact and lysed erythrocyte membranes and inside-out vesicles.(9,10) Obviously, further extensive studies of the organization of glycolipid in other eukaryotic cell membranes are necessary. Interestingly, the majority of neutral glycolipids present in plasma membranes are cryptic (see Section 4.2.1).read more
Citations
More filters
Journal ArticleDOI
Translocation of Activated Heterotrimeric G Protein Gαo to Ganglioside-enriched Detergent-resistant Membrane Rafts in Developing Cerebellum
TL;DR: The association of gangliosides with specific proteins in the central nervous system was examined by co-immunoprecipitation with an anti-ganglioside antibody and the involvement of signal-dependent Gαo translocation to the DRM in the growth cone behavior of cerebellar granule neurons is demonstrated.
Journal ArticleDOI
Prognostic value of the histochemical expression of helix pomatia agglutinin in advanced colorectal cancer : a univariate and multivariate analysis
TL;DR: Histochemical expression of helix pomatia agglutinin will indeed aid in accurately predicting the prognosis of patients with advanced colorectal cancer.
Journal ArticleDOI
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
TL;DR: Pertussis toxin-induced inhibition of DNA synthesis could still be observed even when the toxin was added as late as 6 h after addition of the growth-promoting agents, suggesting the involvement of a GTP-binding protein in a late step of the B subunit- and bombesin-mediated pathways of mitogenesis.
Book ChapterDOI
15 – Role of Basement Membrane in Differentiation
Hynda K. Kleinman,Maura C. Kibbey,H. William Schnaper,Mark A. Hadley,Martin Dym,Derrick S. Grant +5 more
Journal ArticleDOI
Modulation by glycosphingolipids of membrane-membrane interactions induced by myelin basic protein and melittin.
Bruno Maggio,Robert K. Yu +1 more
TL;DR: The results suggest that the modulation by the oligosaccharide chain on the protein-induced interactions between bilayers containing GSLs is probably exerted beyond the level of local molecular interactions between the basic proteins and the lipids.
References
More filters
Journal ArticleDOI
Fibronectins—adhesive glycoproteins of cell surface and blood
Kenneth M. Yamada,Kenneth Olden +1 more
TL;DR: A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids.
Journal ArticleDOI
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
Journal ArticleDOI