Journal ArticleDOI
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
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TLDR
The majority of neutral glycolipids present in plasma membranes are cryptic, and further extensive studies of the organization of glycolIPid in other eukaryotic cell membranes are necessary.Abstract:
The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at the outer leaflet of the plasma membrane bilayer, although this assumption is based only on experiments with surface-labeling by galactose oxidase-NaB[3H]4 of intact and lysed erythrocyte membranes and inside-out vesicles.(9,10) Obviously, further extensive studies of the organization of glycolipid in other eukaryotic cell membranes are necessary. Interestingly, the majority of neutral glycolipids present in plasma membranes are cryptic (see Section 4.2.1).read more
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IgM deposits at nodes of Ranvier in a patient with amyotrophic lateral sclerosis, anti-GM1 antibodies, and multifocal motor conduction block.
Maria Santoro,Florian P. Thomas,Matthew E. Fink,Dale J. Lange,Antonino Uncini,Noshir Wadia,Norman Latov,Arthur P. Hays +7 more
TL;DR: Observed deposits of IgM at nodes of Ranvier suggest that anti‐GM1 antibodies may have caused motor dysfunction by binding to the nodal and paranodal regions of peripheral nerve.
Journal ArticleDOI
Carbohydrate chains specific for blood group antigens in differentiation of human oral epithelium.
TL;DR: A stepwise building up of carbohydrates with blood group specificities during the differentiation of buccal epithelial cells, suggest a stepwise build-up of carbohydrates in the form of N-acetyl-lactosamine and lacto-N-triosyl.
Journal ArticleDOI
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti
Misato Yoshikawa,Shinji Go,Kotaro Takasaki,Yasuhiro Kakazu,Mitsuru Ohashi,Masakazu Nagafuku,Kazuya Kabayama,Junji Sekimoto,Shun Ichi Suzuki,Kazutaka Takaiwa,Takashi Kimitsuki,Nozomu Matsumoto,Shizuo Komune,Daisuke Kamei,Masaki Saito,Michihiro Fujiwara,Katsunori Iwasaki,Jin-ichi Inokuchi +17 more
TL;DR: The defect of hearing ability of SAT-I null mice could be attributed to the functional disorganization of the organ of Corti, and the expression of gangliosides, especially GM3, during the early part of the functional maturation of the cochlea could be essential for the acquisition and maintenance of hearing function.
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Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement.
Mark C. Plucinsky,W. Michael Riley,Joseph J. Prorok,Joseph J. Prorok,Jack A. Alhadeff,Jack A. Alhadeff +5 more
TL;DR: The results show that TSA/TP was the most useful of the markers tested for detecting malignancies and should prove useful for monitoring malignant disease recurrence and/or progression and for evaluating the effectiveness of various therapeutic approaches.
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ABO research in the modern era of genomics.
TL;DR: It is become evident that ABO is a critical player in the modern era of genomic medicine and its understanding of the structures of A and B transferases and their enzymology has been dramatically improved.
References
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Fibronectins—adhesive glycoproteins of cell surface and blood
Kenneth M. Yamada,Kenneth Olden +1 more
TL;DR: A recently characterised class of adhesive, high molecular weight glycoproteins is present on the surfaces of cells, in connective tissue matrices, and in extracellular fluids.
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Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Davor Solter,Barbara B. Knowles +1 more
TL;DR: A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described, which defines an embryonic stage-specific antigen.
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