Journal ArticleDOI
Has the SPRINT trial introduced a new blood-pressure goal in hypertension?
Gema Ruiz-Hurtado,José R. Banegas,Pantelis Sarafidis,Massimo Volpe,Bryan Williams,Luis M. Ruilope +5 more
TLDR
An analysis of the SPRINT data, focusing on patient characteristics, blood-pressure measurement method, and applicability of the findings for future management guidelines, concludes that the results can be applied to other patient populations and geographical areas.Abstract:
SPRINT is the first randomized, controlled trial showing that a systolic blood-pressure goal of <120 mmHg can be attained with cardiovascular benefits in a select group of patients with hypertension and an elevated cardiovascular risk with different origins. Although the patient population with characteristics like those in SPRINT makes up only 20-30% of the total hypertensive population, SPRINT is a landmark study that highlights the need to consider lower blood- pressure goals in the treatment of hypertension. Extending this study to include other patient populations and geographical areas is the next step for evaluating the benefits of strict blood-pressure targets and the generalizability of the SPRINT results. Importantly, the blood-pressure measurement method used in SPRINT differs from previous clinical trials, and raises the issue of whether a more accurate method should be used in clinical trials and if such method is feasible in clinical practice. This Perspectives article provides an analysis of the SPRINT data, focusing on patient characteristics, blood-pressure measurement method, and applicability of the SPRINT findings for future management guidelines.read more
Citations
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Journal ArticleDOI
Highlights of ESC/ESH 2018 Guidelines on the Management of Hypertension: What Every Doctor Should Know
TL;DR: The main new elements introduced in order to meet the need of doctors to adhere to guidelines and to provide their patients with the most updated recommendations for the clinical management of hypertension are focused on.
Journal ArticleDOI
Angiotensin II Type 1 Receptor rs5186 Gene Variant Predicts Incident NAFLD and Associated Hypertension: Role of Dietary Fat-Induced Pro-Inflammatory Cell Activation.
Giovanni Musso,Francesca Saba,Maurizio Cassader,Elena Paschetta,Franco De Michieli,Silvia Pinach,L. Framarin,Berrutti M,Nicola Leone,Renato Parente,Mohammad Taghi Ayoubi Khajekini,Adriana Zarovska,Roberto Gambino +12 more
TL;DR: AGTR1 A1166C variant affects liver disease, insulin resistance, and endothelial dysfunction in NAFLD, at least in part by modulating adipokine, chemokine and pro-inflammatory cell activation in response to fat ingestion.
Journal ArticleDOI
Personalised Single-Pill Combination Therapy in Hypertensive Patients: An Update of a Practical Treatment Platform
Massimo Volpe,Giuliano Tocci,Alejandro de la Sierra,Reinhold Kreutz,Stéphane Laurent,Athanasios J. Manolis,Kostantinos Tsioufis +6 more
TL;DR: An update of the practical therapeutic platform for the treatment of hypertension is presented, which takes into account the results of the recently published studies and extends the applicability of the platform to common conditions that are often neglected or poorly considered in clinical practice guidelines.
Journal ArticleDOI
The optimal blood pressure target in diabetes mellitus: a quest coming to an end?
TL;DR: This review presents the evidence from old and recent trials relevant to optimal BP levels in DM, aiming to shed light in this major clinical question.
Journal ArticleDOI
Emerging Trends in Clinical Research: With Implications for Population Health and Health Policy.
Benjamin Chin-Yee,Benjamin Chin-Yee,S. V. Subramanian,S. V. Subramanian,Amol A. Verma,Amol A. Verma,Amol A. Verma,Andreas Laupacis,Fahad Razak +8 more
TL;DR: Keywords include more expansive strategies for disease prevention, the rise of precision medicine, applications of human microbiome research, and new and highly successful treatments for hepatitis C infection are described.
References
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Journal ArticleDOI
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.
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Journal ArticleDOI
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.
Bernard Zinman,Christoph Wanner,John M. Lachin,David Fitchett,Erich Bluhmki,Stefan Hantel,Michaela Mattheus,Theresa Devins,Odd Erik Johansen,Hans-Juergen Woerle,Uli C. Broedl,Silvio E. Inzucchi +11 more
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Journal ArticleDOI
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TL;DR: Although this guideline provides evidence-based recommendations for the management of high BP and should meet the clinical needs of most patients, these recommendations are not a substitute for clinical judgment, and decisions about care must carefully consider and incorporate the clinical characteristics and circumstances of each individual patient.
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2018 ESC/ESH Guidelines for the management of arterial hypertension.
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2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Robert Fagard,Krzysztof Narkiewicz,Josep Redon,Alberto Zanchetti,Michael Böhm,Thierry Christiaens,Renata Cifkova,Guy De Backer,Anna F. Dominiczak,Maurizio Galderisi,Diederick E. Grobbee,Tiny Jaarsma,Paulus Kirchhof,Sverre E. Kjeldsen,Stéphane Laurent,Athanasios J. Manolis,Peter M. Nilsson,Luis M. Ruilope,Roland E. Schmieder,Per Anton Sirnes,Peter Sleight,Margus Viigimaa,Bernard Waeber,Faiez Zannad,Michel Burnier,Ettore Ambrosioni,Mark Caufield,Antonio Coca,Michael H. Olsen,Costas Tsioufis,Philippe van de Borne,José Luis Zamorano,Stephan Achenbach,Helmut Baumgartner,Jeroen J. Bax,Héctor Bueno,Veronica Dean,Christi Deaton,Çetin Erol,Roberto Ferrari,David Hasdai,Arno W. Hoes,Juhani Knuuti,Philippe Kolh,Patrizio Lancellotti,Aleš Linhart,Petros Nihoyannopoulos,Massimo F Piepoli,Piotr Ponikowski,Juan Tamargo,Michal Tendera,Adam Torbicki,William Wijns,Stephan Windecker,Denis Clement,Thierry C. Gillebert,Enrico Agabiti Rosei,Stefan D. Anker,Johann Bauersachs,Jana Brguljan Hitij,Mark J. Caulfield,Marc De Buyzere,Sabina De Geest,Geneviève Derumeaux,Serap Erdine,Csaba Farsang,Christian Funck-Brentano,Vjekoslav Gerc,Giuseppe Germanò,Stephan Gielen,Herman Haller,Jens Jordan,Thomas Kahan,Michel Komajda,Dragan Lovic,Heiko Mahrholdt,Jan Östergren,Gianfranco Parati,Joep Perk,Jorge Polónia,Bogdan A. Popescu,Zeljko Reiner,Lars Rydén,Yuriy Sirenko,Alice Stanton,Harry A.J. Struijker-Boudier,Charalambos Vlachopoulos,Massimo Volpe,David A. Wood +89 more