Health-related quality of life in narcolepsy.
TLDR
The results showed that the subjects had significantly lower median scores on all eight domains of the SF‐36 than normative data, and scored particularly poorly for the domains of role physical, energy/vitality, and social functioning.Citations
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The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
Journal ArticleDOI
Narcolepsy with cataplexy
TL;DR: Because narcolepsy is an under-recognised disease, it is important that general practitioners and other primary health-care workers identify abnormal daytime sleepiness early.
Journal ArticleDOI
Sleep disturbances and depression: risk relationships for subsequent depression and therapeutic implications.
TL;DR: These findings suggest that sleep-related symptoms that are present before, during, and after a depressive episode are potentially modifiable factors that may play an important role in achieving and maintaining depression remission.
Journal ArticleDOI
Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects
Ronald M. Salomon,Beth Ripley,John S Kennedy,John S Kennedy,Benjamin W. Johnson,Dennis E. Schmidt,Jamie M. Zeitzer,Seiji Nishino,Emmanuel Mignot +8 more
TL;DR: The finding that sertraline but not bupropion slightly decreased cerebrospinal fluid hypocretin-1 indicates a serotoninergic influence on hypocretsin tone, consistent with previous physiologic findings in depression indicating dampened diurnal variations in hypocretIn-1.
References
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An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
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A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
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Validating the SF-36 health survey questionnaire: new outcome measure for primary care.
TL;DR: The SF-36 was able to detect low levels of ill health in patients who had scored 0 (good health) on the Nottingham health profile and is a promising new instrument for measuring health perception in a general population.
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Short form 36 (SF36) health survey questionnaire: normative data for adults of working age.
TL;DR: The SF36 is a potentially valuable tool in medical research and the normative data provided here may further facilitate its validation and use.
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The SF36 health survey questionnaire: an outcome measure suitable for routine use within the NHS?
TL;DR: The SF36 seems acceptable to patients, internally consistent, and a valid measure of the health status of a wide range of patients, and its sensitivity to changes in health status over time must also be tested.