Journal ArticleDOI
Narcolepsy with cataplexy
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TLDR
Because narcolepsy is an under-recognised disease, it is important that general practitioners and other primary health-care workers identify abnormal daytime sleepiness early.About:
This article is published in The Lancet.The article was published on 2007-02-10. It has received 605 citations till now. The article focuses on the topics: Narcolepsy & Cataplexy.read more
Citations
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Journal ArticleDOI
AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland
Hanna Nohynek,Jukka Jokinen,Markku Partinen,Outi Vaarala,Turkka Kirjavainen,Jonas Sundman,Sari-Leena Himanen,Christer Hublin,Ilkka Julkunen,Päivi Olsén,Outi Saarenpää-Heikkilä,Terhi Kilpi +11 more
TL;DR: Pandemrix vaccine contributed to the onset of narcolepsy among those 4 to 19 years old during the pandemic influenza in 2009–2010 in Finland and the role of the adjuvant in particular warrants further research.
Journal ArticleDOI
Classification of Sleep Disorders
TL;DR: The International Classification of Sleep Disorders, version 2, published in 2005 and currently undergoing revision, combines a symptomatic presentation with 1 organized in part on pathophysiology and in parton body systems to more easily differentiate between the disorders.
Journal ArticleDOI
Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland
Markku Partinen,Outi Saarenpää-Heikkilä,Ismo Ilveskoski,Christer Hublin,Miika Linna,Päivi Olsén,Pekka Nokelainen,Reija Alén,Tiina Wallden,Merimaaria Espo,Harri Rusanen,Jan Olme,Heli Sätilä,Harri Arikka,Pekka Kaipainen,Ilkka Julkunen,Turkka Kirjavainen +16 more
TL;DR: A sudden increase in the incidence of abrupt childhood narcolepsy was observed in Finland in 2010 and it is likely that Pandemrix vaccination contributed, perhaps together with other environmental factors, to this increase in genetically susceptible children.
Journal ArticleDOI
Pitolisant versus placebo or modafinil in patients with narcolepsy : a double-blind, randomised trial
Yves Dauvilliers,Claudio L. Bassetti,Gert Jan Lammers,Isabelle Arnulf,Geert Mayer,Andrea Rodenbeck,Philippe Lehert,Philippe Lehert,Claire-Li Ding,Jeanne-Marie Lecomte,J C Schwartz +10 more
TL;DR: Pitolisant at doses up to 40 mg was efficacious on EDS compared with placebo and well tolerated compared with modafinil, and could offer a new treatment option for patients with narcolepsy.
Journal ArticleDOI
Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients
Vesna Cvetkovic-Lopes,Laurence Bayer,Stéphane Dorsaz,Stéphanie Maret,Sylvain Pradervand,Yves Dauvilliers,Michel Lecendreux,Gert Jan Lammers,Claire E H M Donjacour,Renaud Du Pasquier,Corinne Pfister,Brice Petit,Hyun Hor,Michel Muhlethaler,Mehdi Tafti +14 more
TL;DR: Evidence is provided that reactive autoantibodies in human narcolepsy are an autoimmune disorder, provided by ELISA analysis of Serum of a patient showed specific immunoreactivity with over 86% of hypocretin neurons in the mouse hypothalamus.
References
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Journal ArticleDOI
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
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Journal ArticleDOI
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Journal ArticleDOI
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
L de Lecea,Thomas S. Kilduff,Christelle Peyron,Xiao-Bing Gao,Pamela E. Foye,Patria E. Danielson,C. Fukuhara,Elena Battenberg,Vigdis T. Gautvik,Frederick S. Bartlett,Wayne N. Frankel,A. N. van den Pol,Floyd E. Bloom,Kaare M. Gautvik,J G Sutcliffe +14 more
TL;DR: A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters.
Journal ArticleDOI
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Christelle Peyron,Devin K. Tighe,Anthony N. van den Pol,Anthony N. van den Pol,Luis de Lecea,H. Craig Heller,J. Gregor Sutcliffe,Thomas S. Kilduff +7 more
TL;DR: The results of this immunohistochemical study suggest that hypocretins are likely to have a role in physiological functions in addition to food intake such as regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep–waking cycle.
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