Heberden Oration, 1969. Rheumatoid arthritis--nature or nurture?
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The parameters used for assessing arthritis in population samples and the way in which arthritis, encountered in populations, differs from the arthritis which the authors see in the outpatient clinic or in the hospital ward are said to be.Abstract:
Since much of the confusion which has arisen on the influence of heredity and environment in rheumatoid arthritis stems from the employment of population samples as a source of index cases, I should like first to say a few words about the parameters used for assessing arthritis in population samples and about thewayin which arthritis, encountered in populations, differs from the arthritis which we see in the outpatient clinic or in the hospital ward.read more
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Epidemiology and genetics of rheumatoid arthritis.
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A revised estimate of twin concordance in systemic lupus erythematosus
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New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
François Cornelis,Sabine Fauré,Maria Martinez,Jean-François Prud'homme,P Fritz,Colette Dib,Helena Alves,Pilar Barrera,Niek de Vries,Alejandro Balsa,Dora Pascual-Salcedo,Kristin Maenaut,Rene Westhovens,Paola Migliorini,Tuyet-Hoa Tran,A Delaye,Nathalie Prince,Caroline Lefèvre,Gaëlle Thomas,Murielle Poirier,Stéphane Soubigou,Olivier Alibert,Sandra Lasbleiz,Sylvaine Fouix,Christiane Bouchier,Frédéric Lioté,Marie-Noëlle Loste,Virginia Lepage,Dominique Charron,Gabor Gyapay,A. Lopes-Vaz,D. Kuntz,Thomas Bardin,Jean Weissenbach +33 more
TL;DR: This first genome scan in RA Caucasian families revealed 14 candidate regions, one of which was supported further by the study of a second set of families, and could account for 16% of the genetic component of RA.
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Cigarette smoking increases the risk of rheumatoid arthritis : Results from a nationwide study of disease-discordant twins
TL;DR: The discordance in cigarette smoking history for individuals who are at presumed identical genetic risk for RA supports other data suggesting the role of smoking in disease susceptibility.
References
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Book
The clonal selection theory of acquired immunity
TL;DR: The clonal selection theory of acquired immunity is studied as a theory of selection for immunity in the context of infectious disease.
Journal ArticleDOI
The inheritance of liability to certain diseases, estimated from the incidence among relatives
TL;DR: The purpose of this paper is to suggest that the method developed in quantitative genetics for dealing with ‘threshold characters ’ is applicable to data on the incidence of diseases, and that by its use the authors can get further towards an answer to the question of the relative importance of heredity and environment.
Journal ArticleDOI
Generalized Osteoarthritis and Heberden's Nodes
J. H. Kellgren,R. Moore +1 more
TL;DR: He returned to Cambridge for the last years of his life, and he was occupied till the end in writing Some Chapters in Camnbridge Medical History, published in 1946 by the University Press.
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