Journal ArticleDOI
Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: The SIOPEL group experience
Maretta De Ioris,Laurence Brugières,Arthur Zimmermann,Jean W. Keeling,Penelope Brock,Rudolf Maibach,Jon Pritchard,Liz Shafford,Joszef Zsiros,Piotr Czaudzerna,Giorgio Perilongo +10 more
TLDR
This study clearly identifies patients with hepatoblastoma and low serum AFP at diagnosis as a high-risk subgroup with extensive disease at diagnosis, poor response to chemotherapy and a poor outcome.About:
This article is published in European Journal of Cancer.The article was published on 2008-03-01. It has received 135 citations till now. The article focuses on the topics: Hepatoblastoma & Alpha-fetoprotein.read more
Citations
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Journal ArticleDOI
Successful Treatment of Childhood High-Risk Hepatoblastoma With Dose-Intensive Multiagent Chemotherapy and Surgery: Final Results of the SIOPEL-3HR Study
Jozsef Zsiros,Rudolf Maibach,E. Shafford,Laurence Brugières,Penelope Brock,Piotr Czauderna,Derek J. Roebuck,Margaret Childs,Arthur Zimmermann,Véronique Laithier,Jean-Bernard Otte,Beatriz de Camargo,Gordon A. MacKinlay,Marcelo Scopinaro,Daniel C. Aronson,Jack Plaschkes,Giorgio Perilongo +16 more
TL;DR: The applied treatment rendered a great proportion of tumors resectable, and, in comparison with previously published results, led to an improved survival in patients with high-risk hepatoblastoma.
Journal ArticleDOI
Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma
Giorgio Perilongo,Rudolf Maibach,Elisabeth Shafford,Laurence Brugières,Penelope Brock,Bruce Morland,Beatriz de Camargo,Jozsef Zsiros,Derek J. Roebuck,Arthur Zimmermann,Daniel C. Aronson,Margaret Childs,Eva Widing,Véronique Laithier,Jack Plaschkes,Jon Pritchard,Marcello Scopinaro,Gordon A. MacKinlay,Piotr Czauderna +18 more
TL;DR: Cisplatin monotherapy achieved similar rates of complete resection and survival among children with standard-risk hepatoblastoma and doxorubicin can be safely omitted from the treatment of standard- risk hepatoblowlastoma.
Journal ArticleDOI
Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium
Dolores Lopez-Terrada,Rita Alaggio,Maria T. De Dávila,Piotr Czauderna,Eiso Hiyama,Howard M. Katzenstein,Ivo Leuschner,Marcio H. Malogolowkin,Rebecka L. Meyers,Sarangarajan Ranganathan,Yukichi Tanaka,Gail E. Tomlinson,Monique Fabre,Arthur Zimmermann,Milton J. Finegold +14 more
TL;DR: This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology and work towards an International Pediatric Liver Tumors Consensus Classification.
Journal ArticleDOI
Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study
Jozsef Zsiros,Laurence Brugières,Penelope Brock,Derek J. Roebuck,Rudolf Maibach,Arthur Zimmermann,Margaret Childs,Danièle Pariente,Véronique Laithier,Jean-Bernard Otte,Sophie Branchereau,Daniel C. Aronson,Arun Rangaswami,Milind Ronghe,Michela Casanova,Michael J. Sullivan,Bruce Morland,Piotr Czauderna,Giorgio Perilongo +18 more
TL;DR: The SIOPEL-4 treatment regimen is feasible and efficacious for complete remission at the end of treatment for patients with high-risk hepatoblastoma.
Journal ArticleDOI
Complete Surgical Resection Is Curative for Children With Hepatoblastoma With Pure Fetal Histology: A Report From the Children's Oncology Group
Marcio H. Malogolowkin,Howard M. Katzenstein,Rebecka L. Meyers,Mark Krailo,Jon M. Rowland,Joel E. Haas,Milton J. Finegold +6 more
TL;DR: It is shown that surgical resection of hepatoblastoma at diagnosis, without chemotherapy, can identify children for whom no additional therapy is necessary and can achieve long-term survival without additional chemotherapy.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Randomized Comparison of Cisplatin/Vincristine/Fluorouracil and Cisplatin/Continuous Infusion Doxorubicin for Treatment of Pediatric Hepatoblastoma: A Report From the Children’s Cancer Group and the Pediatric Oncology Group
Jorge A. Ortega,Edwin C. Douglass,James H. Feusner,Marleta Reynolds,John J. Quinn,Milton J. Finegold,Joel E. Haas,Denis R. King,Wen Liu-Mares,Martha G. Sensel,Mark Krailo +10 more
TL;DR: Treatment outcome was not significantly different between regimen A and regimen B, and excellent outcome was achieved for patients with stage I-UH and stage II hepatoblastoma and for subsets of patients withStage III disease.
Journal ArticleDOI
Pretreatment prognostic factors for children with hepatoblastoma-- results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1.
Julia Brown,Giorgio Perilongo,E. Shafford,Jean W. Keeling,Jon Pritchard,Penelope Brock,Claire Dicks-Mireaux,Angela Phillips,Anton Vos,Jack Plaschkes +9 more
TL;DR: Tumour focality and enlargement of hilar lymph nodes at diagnosis were univariately associated with EFS, and in multivariate analysis, PRETEXT was the only predictor of OS; PRETEXT and metastases were predictors of EFS.
Journal ArticleDOI
Risk-adapted treatment for childhood hepatoblastoma. final report of the second study of the International Society of Paediatric Oncology--SIOPEL 2.
Giorgio Perilongo,E. Shafford,Rudolf Maibach,Doron Aronson,Laurence Brugières,Penelope Brock,Margaret Childs,Piotr Czauderna,G. MacKinlay,J.B. Otte,Jon Pritchard,R. Rondelli,Marcelo Scopinaro,C.R. Staalman,Jack Plaschkes +14 more
TL;DR: A treatment strategy based on CDDP monotherapy and surgery thus appears effective in SR-HB but, despite CT intensification, only half of the HR-HB patients are long-term survivors.
Journal ArticleDOI
Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma : A successful approach: Results of the first prospective study of the International Society of Pediatric Oncology
Jon Pritchard,Julia Brown,E. Shafford,Giorgio Perilongo,Penelope Brock,Claire Dicks-Mireaux,Jean W. Keeling,Angela Phillips,Anton Vos,Jack Plaschkes +9 more
TL;DR: PLADO chemotherapy and delayed surgery are regarded to be the best available treatment for children with HB and other treatment programs should be measured against this standard.
Related Papers (5)
Successful Treatment of Childhood High-Risk Hepatoblastoma With Dose-Intensive Multiagent Chemotherapy and Surgery: Final Results of the SIOPEL-3HR Study
Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma
Giorgio Perilongo,Rudolf Maibach,Elisabeth Shafford,Laurence Brugières,Penelope Brock,Bruce Morland,Beatriz de Camargo,Jozsef Zsiros,Derek J. Roebuck,Arthur Zimmermann,Daniel C. Aronson,Margaret Childs,Eva Widing,Véronique Laithier,Jack Plaschkes,Jon Pritchard,Marcello Scopinaro,Gordon A. MacKinlay,Piotr Czauderna +18 more