Journal ArticleDOI
HER dimerization inhibitors: developing pertuzumab as an anticancer agent in women's oncology.
Don S. Dizon,Sharmila Makhija +1 more
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TLDR
The results in ovarian cancer have been limited thus far but a post hoc analysis of the results of a completed randomized Phase II trial of gemcitabine with or without pertuzumab suggests that low HER3 levels may mark a group of women who may benefit from the addition of pertuzuab to chemotherapy.Abstract:
Background: Pertuzumab is a novel monoclonal antibody that blocks the dimerization domain of the human epidermal growth factor receptor (HER)-2/neu receptor, disabling its ability to form heterodimers with the other members of its family. Objective: We review the background and scientific rationale, but more specifically cover current clinical trial outcomes of pertuzumab in solid tumors, with an emphasis on the work completed in women's cancers. Methods: Clinical trial results published or presented at national meetings are included in this review. Results: Pertuzumab shows promising activity with trastuzumab in the treatment of metastatic breast cancer. The results in ovarian cancer have been limited thus far but a post hoc analysis of the results of a completed randomized Phase II trial of gemcitabine with or without pertuzumab suggests that low HER3 levels may mark a group of women who may benefit from the addition of pertuzumab to chemotherapy. Conclusions: The efficacy of pertuzumab independent of H...read more
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Journal ArticleDOI
HER-dimerization inhibitors: evaluating pertuzumab in women's cancers.
TL;DR: The background and scientific rationale for pertuzumab, a novel class of agents aimed at blocking HER2 from pairing with other receptors of the HER family, as it has undergone development for women's cancers is discussed.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Journal ArticleDOI
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