Journal ArticleDOI
Hidradenitis suppurativa: A comprehensive review
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TLDR
Hidradenitis suppurativa, also known as acne inversa, is a chronic, often debilitating disease primarily affecting the axillae, perineum, and inframammary regions and is considered a disease of follicular occlusion rather than an inflammatory or infectious process of the apocrine glands.Abstract:
Hidradenitis suppurativa, also known as acne inversa, is a chronic, often debilitating disease primarily affecting the axillae, perineum, and inframammary regions. Prevalence rates of up to 4% have been estimated. Our understanding of the disease has changed over time. It is now considered a disease of follicular occlusion rather than an inflammatory or infectious process of the apocrine glands. Clinically, the disease often presents with tender subcutaneous nodules beginning around puberty. The nodules may spontaneously rupture or coalesce, forming painful, deep dermal abscesses. Eventually, fibrosis and the formation of extensive sinus tracts may result. The location of the lesions may lead to social embarrassment and the failure to seek medical treatment. Therapies in the past have consisted of long-term antibiotics, antiandrogens, and surgery. New treatments like tumor necrosis factor-alfa inhibitors have given clinicians more options against this difficult disease.read more
Citations
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Journal ArticleDOI
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
Dennis L. Stevens,Alan L. Bisno,Henry F. Chambers,E. Patchen Dellinger,Ellie J. C. Goldstein,Sherwood L. Gorbach,Jan V. Hirschmann,Sheldon L. Kaplan,Jose G. Montoya,James C. Wade,R. M. Alden +10 more
TL;DR: This guideline addresses the wide array of SSTIs that occur in this population and emphasizes the importance of clinical skills in promptly diagnosing SSTI, identifying the pathogen, and administering effective treatments in a timely fashion.
Journal ArticleDOI
Executive Summary: Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
Dennis L. Stevens,Alan L. Bisno,Henry F. Chambers,E. Patchen Dellinger,Ellie J. C. Goldstein,Sherwood L. Gorbach,Jan V. Hirschmann,Sheldon L. Kaplan,Jose G. Montoya,James C. Wade +9 more
TL;DR: This guideline addresses the wide array of SSTIs that occur in this population and emphasizes the importance of clinical skills in promptly diagnosing SSTI, identifying the pathogen, and administering effective treatments in a timely fashion.
Journal ArticleDOI
European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa
Christos C. Zouboulis,N. Desai,Lennart Emtestam,Robert E. Hunger,Demetris Ioannides,István Juhász,Jan Lapins,Lukasz Matusiak,Errol P. Prens,Jean Revuz,S Schneider-Burrus,Jacek C Szepietowski,H.H. van der Zee,Gregor B.E. Jemec +13 more
TL;DR: Hidradenitis suppurativa/acne inversa is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated, inflamed lesions in the apocrine gland‐bearing areas of the body.
Journal ArticleDOI
Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β.
H.H. van der Zee,L. de Ruiter,D.G. van den Broecke,Willem A. Dik,Jon D. Laman,Errol P. Prens +5 more
TL;DR: Although it is not known whether the levels of tumour necrosis factor (TNF)‐α are aberrant in HS skin, anti‐TNF‐α biologics are used, with variable clinical efficacy.
Journal ArticleDOI
Adalimumab for the Treatment of Moderate to Severe Hidradenitis Suppurativa: A Parallel Randomized Trial
Alexa B. Kimball,Francisco A. Kerdel,David Adams,Ulrich Mrowietz,Joel M. Gelfand,Robert Gniadecki,Errol P. Prens,Joel Schlessinger,Christos C. Zouboulis,Hessel H. van der Zee,Marie R. Rosenfeld,Parvez Mulani,Yihua Gu,Susan K. Paulson,Martin M. Okun,Gregor B.E. Jemec +15 more
TL;DR: Adalimumab dosed once per week alleviates moderate to severe HS and significantly greater improvements in patient-reported outcomes and pain were seen in the weekly dosing group than in the placebo group.
References
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Journal ArticleDOI
Anti-TNF Antibody Therapy in Rheumatoid Arthritis and the Risk of Serious Infections and Malignancies: Systematic Review and Meta-analysis of Rare Harmful Effects in Randomized Controlled Trials
Tim Bongartz,Alex J. Sutton,Michael J. Sweeting,Iain Buchan,Eric L. Matteson,Victor M. Montori +5 more
TL;DR: There is evidence of an increased risk of serious infections and a dose-dependent increasedrisk of malignancies in patients with rheumatoid arthritis treated with anti-TNF antibody therapy.
Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics
Alan Menter,Alice B. Gottlieb,Steven R. Feldman,Abby S. Van Voorhees,Craig L. Leonardi,Kenneth B. Gordon,Mark Lebwohl,John Koo,Craig A. Elmets,Neil J. Korman,Karl R. Beutner,Reva Bhushan +11 more
TL;DR: The classification of psoriasis; associated comorbidities including autoimmune diseases, cardiovascular risk, psychiatric/psychologic issues, and cancer risk; along with assessment tools for skin disease and quality-of-life issues; and the safety and efficacy of the biologic treatments used to treat patients with Psoriasis are discussed.
Journal ArticleDOI
Granulomatous Infectious Diseases Associated with Tumor Necrosis Factor Antagonists
TL;DR: The clustering of reports shortly after initiation of treatment with infliximab is consistent with reactivation of latent infection, and a risk of granulomatous infection was 3.25-fold greater among patients who received inflIXimab than among those who received etanercept.
Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: Overview and guidelines of care for treatment with an emphasis on the biologics
Alice B. Gottlieb,Neil J. Korman,Kenneth B. Gordon,Steven R. Feldman,Mark Lebwohl,John Koo,Abby S. Van Voorhees,Craig A. Elmets,Craig L. Leonardi,Karl R. Beutner,Reva Bhushan,Alan Menter +11 more
TL;DR: An overview of psoriasis including its cardinal clinical features, pathogenesis, prognosis, classification, assessment tools used to evaluate psoriatic arthritis, and the approach to treatment is given.