High glucose can induce lipid peroxidation in the isolated rat glomeruli
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The data suggest that elevated glucose levels per se can cause oxidative stress and augment membrane lipid peroxidation of glomeruli, and activation of PKC may play a role in early phase of glucose-induced glomerular lipid per oxidation.About:
This article is published in Kidney International.The article was published on 1994-12-01 and is currently open access. It has received 56 citations till now. The article focuses on the topics: Lipid peroxidation.read more
Citations
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Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.
TL;DR: Long-term administration of antioxidants can inhibit the development of the early stages of diabetic retinopathy, and the mechanism by which this action occurs warrants further investigation.
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NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology
TL;DR: The aim of this review is to provide an overview of the emerging area of ROS derived from NADPH oxidase and oxidant signaling in ECs linked to physiological and pathophysiological functions, and to provide insight into the NADPH oxidation components as potential therapeutic targets.
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Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.
TL;DR: Alterations associated with oxidative stress offer many potential therapeutic targets making this an area of great interest to the development of safe and effective treatments for diabetic retinopathy.
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High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells.
TL;DR: It is shown that increased glucose caused inhibition of G6PD resulting in decreased NADPH levels in bovine aortic endothelial cells (BAEC) and that changes in G6 PD activity play an important role in high glucose-induced cell damage/death.
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High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells
Tusty-Jiuan Hsieh,Shao-Ling Zhang,János G. Filep,Shiow-Shih Tang,Julie R. Ingelfinger,John S.D. Chan +5 more
TL;DR: It is demonstrated that the stimulatory action of high glucose on Angiotensinogen gene expression in IRPTCs is mediated at least in part via ROS generation and subsequent p38 MAPK activation.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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Role of Oxidative Stress in Development of Complications in Diabetes
TL;DR: Structural characterization of the cross-links and other products accumulating in collagen in diabetes is needed to gain a better understanding of the relationship between oxidative stress and the development of complications in diabetes.
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
TL;DR: Both the holoenzyme and the catalytic subunit (or fragment), which is active without an enzyme activator, are susceptible to these compounds with a similar concentration dependency, thereby indicating that the inhibitory effect is attributed to the direct interaction of the compound with the active center of the enzyme but not with the enzymeactivator.
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Cellular defenses against damage from reactive oxygen species
TL;DR: Ceruloplasmin should appear as follows: [See PDF]