High resolution whole brain imaging of anatomical variation in XO, XX, and XY mice.
TLDR
It is demonstrated that murine X-monosomy (XO) causes accentuation of XX vs XY differences in a set of sexually dimorphic structures including classical foci of sex-hormone action, and an evolutionarily conserved influence of X-linked genes on both cortical and subcortical development in mammals.About:
This article is published in NeuroImage.The article was published on 2013-12-01 and is currently open access. It has received 35 citations till now. The article focuses on the topics: X chromosome & Stria terminalis.read more
Citations
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Sex differences in anxiety and depression clinical perspectives
TL;DR: Clinical aspects of sex differences in affective disorders including the emergence ofsex differences across developmental stages and the impact of reproductive events are focused on.
Journal ArticleDOI
Imaging sex/gender and autism in the brain: Etiological implications
Meng-Chuan Lai,Jason P. Lerch,Dorothea L. Floris,Amber N. V. Ruigrok,Alexa Pohl,Michael V. Lombardo,Simon Baron-Cohen +6 more
TL;DR: Both human and animal studies converge to indicate that the brain characteristics of autism are partly associated with normative brain sex/gender differences, suggesting convergence or overlap between the mechanisms leading to and modifying the development of autism and the mechanisms underlying sex differentiation and/or gender socialization.
Journal ArticleDOI
Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies
TL;DR: Overall an increased rate of attention-deficit hyperactivity disorder and autism spectrum disorder is described, along with the increased rates of major depressive disorder and anxiety disorders in one or more of these conditions.
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Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism
TL;DR: Behavioral outcomes and neuroanatomical abnormalities are summarized from multiple mouse models of autism spectrum disorder and comorbid syndromes, with a focus on high-resolution magnetic resonance imaging of postmortem mouse brains.
Journal ArticleDOI
Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development
Armin Raznahan,Nancy Raitano Lee,Deanna Greenstein,Gregory L. Wallace,Jonathan D. Blumenthal,Liv S. Clasen,Jay N. Giedd +6 more
TL;DR: Convergent X-Y effects track the dosage of those few genes that are still shared by X- and Y-chromosomes, and may provide a biological substrate for the link between SCA and increased rates of psychopathology.
References
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