Journal ArticleDOI
Higher α1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: Further evidence for the existence of an inflammatory response during that illness
Marie-Berthe Maes,Simon Scharpé,Simon Scharpé,L. Van Grootel,W. Uyttenbroeck,W. Uyttenbroeck,W. Cooreman,W. Cooreman,Paul Cosyns,E. Suy +9 more
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TLDR
Increased plasma concentrations of Hp, alpha 1AT, and Cp in major depressed subjects as compared with healthy controls, with minor depressives exhibiting an intermediate position, are compatible with the hypothesis that major depression may be accompanied by inflammatory changes with higher levels of positive APPs.About:
This article is published in Journal of Affective Disorders.The article was published on 1992-03-01. It has received 153 citations till now. The article focuses on the topics: Retinol binding protein & Acute-phase protein.read more
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The relationship of depression and stressors to immunological assays: a meta-analytic review.
Eric P. Zorrilla,Lester Luborsky,James R. McKay,Robert Rosenthal,Arlene D. Houldin,Anne Tax,Ruth McCorkle,David A. Seligman,Kelly Schmidt +8 more
TL;DR: A broad meta-analysis of the relations of both depression and stressors to immunological assays revealed that for both major depression and naturally occurring stressors the following effects are shared: leukocytosis, increased CD4/CD8 ratios, reduced proliferative response to mitogen, and reduced NK cell cytotoxicity.
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Evidence for an immune response in major depression: a review and hypothesis
TL;DR: It is hypothesized that increased monocytic production of interleukins (Il-1 beta and Il-6) in severe depression may constitute key phenomena underlying the various aspects of the immune and "acute" phase response, while contributing to hypothalamic-pituitary-adrenal-axis hyperactivity, disorders in serotonin metabolism, and to the vegetative symptoms of severe depression.
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Biological and clinical significance of haptoglobin polymorphism in humans.
TL;DR: The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology and is explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis.
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Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies.
Cristiano A. Köhler,Thiago H. Freitas,Michael Maes,N. Q. De Andrade,Celina S. Liu,Brisa Simoes Fernandes,Brisa Simoes Fernandes,Brendon Stubbs,Brendon Stubbs,Marco Solmi,Nicola Veronese,Nathan Herrmann,Charles L. Raison,Brian J. Miller,Krista L. Lanctôt,André F. Carvalho +15 more
TL;DR: A systematic review and meta‐analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs) is conducted.
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Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression.
TL;DR: Age, samples source and ethnic origins may play a potential role in heterogeneity, and European but not non-European subjects have higher levels difference of sIL-2R, TNF-α and IL-1β between MDD patients and controls.
References
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A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
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The phenomenon of the acute phase response
TL;DR: Avery never discussed the C-reactive protein without turning the conversation to what he was wont to call “the chemistry of the host,” which clearly had in mind all the unidentified body substances and mechanisms of a nonimmunological nature that come into play in the course of infectious processes.
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Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
José V. Castell,María José Gómez-Lechón,Martina David,Tilo Andus,Thomas Geiger,Ramón Trullenque,Ricardo Fabra,Peter C. Heinrich +7 more
TL;DR: The data suggest that IL‐6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.
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Lymphocyte Function in Major Depressive Disorder
Steven J. Schleifer,Steven E. Keller,Arthur T. Meyerson,Marjorie Raskin,Kenneth L. Davis,Marvin Stein +5 more
TL;DR: Lymphocyte stimulation by phytohemagglutinin, concanavalin A, and pokeweed mitogen was significantly lower in a group of hospitalized depressed patients than in matched controls, which may be related to the altered neuroendocrine function found in patients with depressive disorders.