Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways.
Ayesha Sarfraz,Azhar Rasul,Iqra Sarfraz,Muhammad Ajmal Shah,Ghulam Hussain,Nusrat Shafiq,Muqaddas Masood,Şevki Adem,Satyajit D. Sarker,Xiaomeng Li +9 more
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TLDR
It is proposed that hispolon provides a novel opportunity for pharmacological applications and its styrylpyrone carbon skeleton might serve as an attractive scaffold for drug development, and future researchers are recommended to assess bioavailability, toxicological limits, pharmacokinetic and pharmacodynamic profiles of hisPolon, in order to establish its potential as a potent multi-targeted drug in the near future.About:
This article is published in Environmental Research.The article was published on 2020-08-06 and is currently open access. It has received 33 citations till now. The article focuses on the topics: Hispolon & Drug development.read more
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Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis
Milad Ashrafizadeh,Mohammad Hossein Gholami,Sepideh Mirzaei,Amirhossein Zabolian,Amirabbas Haddadi,Mahdi Vasheghani Farahani,Sharareh Hosseinzadeh Kashani,Kiavash Hushmandi,Masoud Najafi,Ali Zarrabi,Kwang Seok Ahn,Haroon Khan +11 more
TL;DR: In this paper, the authors described complicated signaling networks for proliferation and invasion of cancer cells that need to be elucidated for providing effective cancer therapy, and minimizing their malignancy.
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Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis.
Hueng-Chuen Fan,Ya Chu Hsieh,Li Hsuan Li,Ching Chin Chang,Karolína Janoušková,Karolína Janoušková,Modukuri V. Ramani,Gottumukkala V. Subbaraju,Kur Ta Cheng,Chia Che Chang +9 more
TL;DR: DHME was found to be more cytotoxic than hispolon against a panel of human CRC cell lines, while exerting limited toxicity to normal human colon cell line CCD 841 CoN, and provoking CRC cell apoptosis via suppression of the WNT/β-catenin signaling axis.
References
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