Homocysteine, vitamin B12 and folate levels in premature coronary artery disease.
Saeed Sadeghian,Faramarz Fallahi,Mojtaba Salarifar,Gholamreza Davoodi,Mehran Mahmoodian,Nader Fallah,Soodabeh Darvish,Abbasali Karimi +7 more
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TLDR
It is concluded that hyperhomocysteinemia is an independent risk factor for CAD in young patients (bellow 45 years old) – especially in men -and vitamin B12 deficiency is a preventable cause of hyperhomocytesteinemia.Abstract:
Background
Hyperhomocysteinemia is known as an independent risk factor of atherosclerosis, but the probable role of hyperhomocysteinemia in premature Coronary Artery Disease (CAD) is not well studied. The aim of this study was to assess the role of hyperhomocysteinemia, folate and Vitamin B12 deficiency in the development of premature CAD.read more
Citations
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Journal ArticleDOI
Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease
TL;DR: Serum vitamin B12 deficiency and hyperhomocysteinemia are related with cardiovascular risk factors in Indian patients with CAD.
Journal ArticleDOI
Coronary artery disease and its risk factors status in iran: a review.
Mahmoud Ebrahimi,Seyyed Mohammad Reza Kazemi-Bajestani,Majid Ghayour-Mobarhan,Majid Ghayour-Mobarhan,G. Ferns +4 more
TL;DR: Primary and secondary prevention of CAD including life style modifications and dietary interventions strongly recommended in Iranian population are strongly recommended.
Journal ArticleDOI
Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
Davis Kibirige,Raymond Mwebaze +1 more
TL;DR: A current perspective is offered on the physiological roles of vitamin B12, proposed pathophysiological mechanisms of vitamins B12 deficiency, screening for vitamin B 12 deficiency anditamin B12 supplementation among patients with diabetes mellitus.
Journal ArticleDOI
Unexplained decline in the prevalence of anemia among US children and women between 1988-1994 and 1999-2002
Sarah E. Cusick,Zuguo Mei,David S. Freedman,Anne C. Looker,Cynthia L. Ogden,Elaine W. Gunter,Mary E. Cogswell +6 more
TL;DR: The prevalence of anemia declined significantly among US women and children between 1988-1994 and 1999-2002, but this decline was not associated with changes in iron or folate deficiency, inflammation, or high blood lead.
Journal ArticleDOI
Association Between Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) C677T and Risk of Myocardial Infarction: A Meta-Analysis for 8,140 Cases and 10,522 Controls
TL;DR: Meta-analysis results suggest that the MTHFR C677T polymorphism was associated with risk of MI in young/middle-aged Caucasians, and the effect of the variants on the expression levels and the possible functional role of the variant in MI should be addressed in further studies.
References
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Journal ArticleDOI
Hyperhomocysteinemia: an independent risk factor for vascular disease.
Robert Clarke,Leslie Daly,Killian Robinson,E. R. Naughten,Seamus F. Cahalane,Brian Fowler,Ian D. Graham +6 more
TL;DR: Hyperhomocysteinemia is an independent risk factor for vascular disease, including coronary disease, and in most instances is probably due to cystathionine beta-synthase deficiency.
Journal ArticleDOI
Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population
TL;DR: A strong association between homocysteine concentration and folate, vitamin B12, and vitamin B6 status, as well as age is indicated, suggesting that a substantial majority of the cases of high homocy steine in this older population can be attributed to vitamin status.
Journal ArticleDOI
Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project.
Graham Im,Leslie Daly,Helga Refsum,Killian Robinson,Lars Brattström,Per Magne Ueland,Roberto Palma-Reis,Godfried H.J. Boers,Richard G. Sheahan,Israelsson B,Cuno S.P.M. Uiterwaal,Raymond Meleady,Dorothy McMaster,Petra Verhoef,Jacqueline C.M. Witteman,Paolo Rubba,Bellet H,Jan C. Wautrecht,de Valk Hw,Sales Lúis Ac,Parrot-Rouland Fm,K.S. Tan,I.M. Higgins,Danielle Garcon,Generoso Andria +24 more
TL;DR: An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia, and compared with nonusers of vitamin supplements, the small number of subjects taking such vitamins appeared to have a substantially lower risk ofascular disease, a proportion of which was attributable to lower plasma homocy steine levels.
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