Journal ArticleDOI
Honeycomb-Satellite Structured pH/H2O2-Responsive Degradable Nanoplatform for Efficient Photodynamic Therapy and Multimodal Imaging
Qianqian Sun,Fei He,Chunqiang Sun,Xiangxi Wang,Chunxia Li,Jiating Xu,Dan Yang,Huiting Bi,Gai Shili,Piaoping Yang +9 more
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TLDR
The in vitro and in vivo experiments demonstrate that hMUC sample with the honeycomb-satellite structure can serve as multimodal bioimaging contrast agent for self-enhanced upconversion luminescence (UCL), magnetic resonance imaging (MRI) and computed tomography (CT) imaging, indicating that the as-prepared hM UC could be used in imaging-guided diagnosis and treatment.Abstract:
The oxygen-deprived environment of a solid tumor is still great restriction in achieving an efficient photodynamic therapy (PDT). In this work, we developed a smart pH-controllable and H2O2-responsive nanoplatform with degradable property, which was based on honeycomb manganese oxide (hMnO2) nanospheres loaded with Ce6-sensitized core–shell–shell structured up-conversion nanoparticles (NaGdF4:Yb/Er,Tm@NaGdF4:Yb@NaNdF4:Yb) (abbreviated as hMUC). In the system, the speedy breakup of the as-prepared hMnO2 nanostructures results in release of loaded Ce6-sensitized UCNPs under the condition of H2O2 in acid solution. When exposed to tissue-penetrable 808 nm laser, up-conversion nanoparticles (UCNPs) emit higher-energy visible photons which would be absorbed by Ce6 to yield cytotoxic reactive oxygen species (ROS), thus triggering PDT treatment naturally. Moreover, the in vitro and in vivo experiments demonstrate that hMUC sample with the honeycomb-satellite structure can serve as multimodal bioimaging contrast a...read more
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Journal ArticleDOI
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
TL;DR: The representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced.
Journal ArticleDOI
A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging
TL;DR: Through the subsequent synergistic cross-activation between HCR and DNAzyme amplicons, the ACD amplifier turns the limited miRNA-recognition into tremendously amplified readout, thus contributing to the accurate tumor diagnosis.
Journal ArticleDOI
MnO2-Disguised Upconversion Hybrid Nanocomposite: An Ideal Architecture for Tumor Microenvironment-Triggered UCL/MR Bioimaging and Enhanced Chemodynamic Therapy
Binbin Ding,Binbin Ding,Shuai Shao,Shuai Shao,Fan Jiang,Fan Jiang,Peipei Dang,Peipei Dang,Chunqiang Sun,Shanshan Huang,Ping'an Ma,Ping'an Ma,Dayong Jin,Abdulaziz A. Al Kheraif,Jun Lin,Jun Lin +15 more
TL;DR: A simple and versatile strategy for the in situ growth of MnO2 on the surfaces of UCNPs was reported using a sacrificial template method to construct an ideal MnO 2-disguised and tumor microenvironment–triggered architecture.
Journal ArticleDOI
Construction of Bi/phthalocyanine manganese nanocomposite for trimodal imaging directed photodynamic and photothermal therapy mediated by 808 nm light.
Zhao Wang,Tao Jia,Qianqian Sun,Ye Kuang,Bin Liu,Mengshu Xu,Hui Zhu,Fei He,Shili Gai,Piaoping Yang +9 more
TL;DR: In vivo fluorescence imaging vividly showed that the nanocomposite rapidly accumulates in tumor sites due to the enhanced permeability and retention (EPR) effect and metabolized in the organs, implying that the Nanocomposites have a high potential for use in imaging directed tumor therapy.
Journal ArticleDOI
Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy.
TL;DR: Recent advances in the use of MONs as MRI contrast agents for tumor detection and diagnosis are reported, as are the advances in in vivo toxicity, distribution and tumor microenvironment-responsive enhanced tumor chemotherapy and radiotherapy as well as photothermal and photodynamic therapies.
References
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Journal ArticleDOI
Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH‐/H2O2‐Responsive UCL Imaging and Oxygen‐Elevated Synergetic Therapy
Wenpei Fan,Wenbo Bu,Wenbo Bu,Bo Shen,Qianjun He,Zhaowen Cui,Yanyan Liu,Xiangpeng Zheng,Kuaile Zhao,Jianlin Shi +9 more
TL;DR: Dr. W. Bu Jiangsu Collaborative Innovation Center for Advanced Inorganic Functional Composites Nanjing Tech University Nanjing 210009 and Prof. J. Shi State Key Laboratory of High Performance Ceramics and Superfi ne Microstructures Shanghai Institute of Ceramic Chinese Academy of Sciences Shanghai 200050.
Journal ArticleDOI
Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer
Jun Xu,Ligeng Xu,Chenya Wang,Rong Yang,Qi Zhuang,Xiao Han,Ziliang Dong,Wenwen Zhu,Rui Peng,Zhuang Liu +9 more
TL;DR: This work presents an immune-stimulating UCNP-based PDT strategy in combination with CTLA-4 checkpoint blockade to effectively destroy primary tumors under light exposure, inhibit distant tumors that can hardly be reached by light, and prevent tumor reoccurrence via the immune memory effect.