Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL.
TLDR
It is demonstrated that CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, VLDL, and, as previously reported, for OxLDL and AcLDL.About:
This article is published in Journal of Lipid Research.The article was published on 1998-04-01 and is currently open access. It has received 374 citations till now. The article focuses on the topics: Foam cell & CD36.read more
Citations
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Journal ArticleDOI
A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.
Maria Febbraio,Nada A. Abumrad,David P. Hajjar,Kavita Sharma,Wanli Cheng,S. Frieda A. Pearce,Roy L. Silverstein +6 more
TL;DR: Evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated is provided.
Journal ArticleDOI
Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
Timothy J. Aitman,Anne M. Glazier,Caroline A. Wallace,Lisa D. Cooper,Penny J. Norsworthy,Faisal N. Wahid,Khulood M. Al-Majali,Paul M. Trembling,Christopher J. Mann,Carol C. Shoulders,Daniel Graf,Elizabeth St. Lezin,Theodore W. Kurtz,Vladimir Kren,Vladimir Kren,M Pravenec,M Pravenec,Azeddine Ibrahimi,Nada A. Abumrad,Lawrence W. Stanton,James Scott +20 more
TL;DR: It is concluded that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes.
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Reprogramming of fatty acid metabolism in cancer
TL;DR: This review will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research, including the role of de novo synthesis and exogenous uptake in the cellular pool of fatty acids.
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HDL and arteriosclerosis: beyond reverse cholesterol transport.
Jerzy-Roch Nofer,Beate E. Kehrel,Manfred Fobker,Bodo Levkau,Gerd Assmann,Arnold von Eckardstein +5 more
TL;DR: In this article, the anti-atherogenic properties of HDL have been investigated and the concept of reverse cholesterol transport has been reviewed, which describes both the metabolism and the classic anti-athrogenic function of HDL (Arterioscler. Thromb. Vasc. 20 2001 13).
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Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
TL;DR: Recent advances in knowledge of scavenger receptor regulation and signal transduction are focused on, their roles in sterile inflammation and infection, and the potential impact of these pathways in regulating the balance of lipid accumulation and inflammation in the artery wall.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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High density lipoprotein as a protective factor against coronary heart disease: The Framingham study
TL;DR: The major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease in either men or women and these associations were equally significant even when other lipids and other standard risk factors for coronaryHeart disease were taken into consideration.
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Role of oxidized low density lipoprotein in atherogenesis.
TL;DR: New ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.
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Binding Site on Macrophages that Mediates Uptake and Degradation of Acetylated Low Density Lipoprotein, Producing Massive Cholesterol Deposition
TL;DR: It is hypothesized that this macrophage uptake mechanism may mediate the degradation of denatured LDL in the body and thus serve as a "backup" mechanism for the previously described receptor-mediated degradation of native LDL that occurs in parenchymal cells.
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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Joseph L. Goldstein,M. S. Brown +1 more
TL;DR: The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.