Journal ArticleDOI
Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707m.
David L. Baker,Usha R. Reddy,Samuel J. Pleasure,Mattie Hardy,Marge Williams,Margaret Tartaglione,Jaclyn A. Biegel,Beverly S. Emanuel,Patrizia Lo Presti,Barbara Kreider,John Q. Trojanowski,Audrey E. Evans,Amit R. Roy,Gita Venkatakrishnan,Jie Chen,Alonzo H. Ross,David E Pleasure +16 more
TLDR
Although CHP707m is the first central nervous system PNET cell line proven to express NGF receptors, immunohistological survey of tissue sections prepared from human central nervous System PNETs showed that 13 of 35 contained NGF receptor‐positive tumor cells, suggesting more than one‐third of such tumors might be responsive to the effects of NGF.Citations
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Identification of a truncated form of the nerve growth factor receptor (Schwann cell/axotomy/development/urine composition/plasma composition)
TL;DR: It is demonstrated that cultured Schwann cells shed a truncated (50-kDa) form of the NGF receptor (NGF-Rt) into their medium, suggesting that the developmentally regulated release of NGF-RT, present in plasma and other body fluids, plays a regulatory role in nervous system development.
Journal ArticleDOI
Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer.
Jens Bühren,Arndt H.A. Christoph,Rolf Buslei,Steffen Albrecht,Otmar D. Wiestler,Torsten Pietsch +5 more
TL;DR: Since the neurotrophin receptor p75NTR is expressed in cells of the external granule cell layer (EGL) of the fetal cerebellum, the findings suggest that progenitor cells ofThe EGL are the cellular origin of a distinct subset of MB, namely the desmoplastic variant and MBs with a significant desm Plastic component.
Journal ArticleDOI
High expression of somatostatin receptor subtype 2 (sst2) in medulloblastoma: implications for diagnosis and therapy.
TL;DR: Both sst1 and sst2 are highly expressed in cPNET and it is suggested that somatostatin may regulate proliferation and differentiation in these developmental tumors.
Journal Article
Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system
Kazuo Washiyama,Yoshihiro Muragaki,Lucy B. Rorke,Virginia M.-Y. Lee,Stuart C. Feinstein,Monte J. Radeke,Deborah Blumberg,David L. Kaplan,John Q. Trojanowski +8 more
TL;DR: The demonstration here that neurotrophins and their cognate receptor proteins are expressed in PNETs as well as in other pediatric brain tumors may imply that signal transduction pathways mediated by neurotrophin and/or their receptors influence the induction or progression of these common childhood neoplasms.
Journal ArticleDOI
Medulloblastomas and related primitive neuroectodermal brain tumors of childhood recapitulate molecular milestones in the maturation of neuroblasts.
TL;DR: Recent data are reviewed that suggest that neoplastic cells in childhood primitive neuroectodermal tumors (PNETs) of the central nervous system may represent a cluster of molecular abnormalities that underly the emergence of the highly malignant phenotype that characterizes childhood PNETs.
References
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Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
TL;DR: A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma and should be a useful model system for neurobiological and neurochemical studies.
Book
Pathology of Tumours of the Nervous System
TL;DR: Pathology of Tumours of the Nervous System, by Dorothy S. Russell, Sc.D.
Journal ArticleDOI
Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas.
Robert C. Seeger,Garrett M. Brodeur,Harland N. Sather,Andree Dalton,Stuart E. Siegel,Kwan Y. Wong,Denman Hammond +6 more
TL;DR: The results suggest that genomic amplification of N-myc may have a key role in determining the aggressiveness of neuroblastomas.
Journal ArticleDOI
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Manfred Schwab,Kari Alitalo,Karl-Heinz Klempnauer,Harold E. Varmus,J. Michael Bishop,Fred Gilbert,Garrett M. Brodeur,Milton I. Goldstein,Jeffrey M. Trent +8 more
TL;DR: It is shown here that a DNA domain detectable by partial homology to the myc oncogene is amplified up to 140-fold in cell lines derived from different human neuroblastomas and in a neuroblastoma tumour, but not in other tumour cells showing cytological evidence for gene amplification.